What is the most common cause of chorioretinal scar in children?

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From the Guidelines

Toxoplasma retinochoroiditis is the most common cause of chorioretinal scar in children.

Causes of Chorioretinal Scars

  • Toxoplasma retinochoroiditis is a leading cause of chorioretinal scars in children, as it is a common cause of uveitis in this population 1.
  • Other causes of uveitis, such as juvenile idiopathic arthritis, can also lead to chorioretinal scars, but toxoplasma retinochoroiditis is the most frequent specific cause 1.
  • Ocular toxoplasmosis typically appears as white retinal lesions with little associated hemorrhage and can result in visual loss 1.

Diagnosis and Treatment

  • Prompt diagnosis and treatment of uveitis, including toxoplasma retinochoroiditis, are critical to preserving visual function 1.
  • Children with suspected toxoplasma retinochoroiditis should undergo a neurologic examination, as isolated ocular toxoplasmosis is rare and often occurs in association with CNS infection 1.

From the Research

Causes of Chorioretinal Scars in Children

  • Chorioretinal scars are a common eye finding in children, particularly in those with congenital infections 2, 3, 4
  • The most common cause of chorioretinal scars in children is congenital toxoplasmosis, which can result in macular scars and visual impairment 2, 3
  • Other causes of chorioretinal scars in children include:
    • Congenital lymphocytic choriomeningitis virus (LCMV) infection 5
    • Congenital varicella syndrome 6
    • Cytomegalovirus (CMV) infection 4
    • Herpes simplex virus (HSV) infection 4
  • Chorioretinal scars can also be associated with other ocular findings, such as optic atrophy, cataracts, and retinal detachment 2, 5, 4, 6

Characteristics of Chorioretinal Scars

  • Chorioretinal scars can be located in the macular region or periphery of the retina 2, 3
  • Macular scars can result in visual impairment, ranging from mild to severe 2, 3
  • Chorioretinal scars can be active or quiescent, and may recur over time 2, 3
  • The presence of chorioretinal scars can be an indication of an underlying congenital infection, and further testing may be necessary to determine the cause 3, 5, 4, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Eye manifestations of congenital toxoplasmosis.

American journal of ophthalmology, 1997

Research

[Congenital toxoplasmosis: presentation of a case].

Bulletin de la Societe belge d'ophtalmologie, 1999

Research

Eye manifestations of intrauterine infections.

Ophthalmology clinics of North America, 2001

Research

Childhood blindness and visual loss: an assessment at two institutions including a "new" cause.

Transactions of the American Ophthalmological Society, 1999

Research

Ocular manifestations of the congenital varicella syndrome.

Archives of ophthalmology (Chicago, Ill. : 1960), 1989

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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