What is Shoulder Injury Related to Vaccine Administration (SIRVA)?

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Last updated: February 11, 2025View editorial policy

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From the Research

Definition and Causes of SIRVA

  • Shoulder Injury Related to Vaccine Administration (SIRVA) is a recognized complication and possible source of morbidity associated with incorrectly administered intramuscular deltoid vaccinations 1.
  • SIRVA is postulated to be an immune-mediated inflammatory response to a vaccine antigen injected into or near the subacromial bursae or synovium, leading to shoulder pain and dysfunction 2.
  • The condition can occur when an intramuscular deltoid injection is administered into the shoulder joint 3.

Clinical Characteristics and Diagnoses

  • Patients with SIRVA typically present with severe pain and limited range of motion within 48 hours of vaccination 4.
  • The most common symptoms are shoulder pain and reduced range of motion (ROM) 2.
  • The most common diagnoses are shoulder bursitis, adhesive capsulitis, and rotator cuff tears 2.
  • Adhesive capsulitis is the most common diagnosis, followed by bursitis and supraspinatus tear 3.

Management Approaches and Outcomes

  • The most frequent management modalities include physical or occupational therapy, NSAIDs, and steroid injections, followed by surgery 2.
  • Full resolution of symptoms is reported in 2.9% to 56% of patients 2.
  • Conservative care, such as exercise and manual therapies, can be effective in reducing pain and improving shoulder ROM 3.
  • Surgery may be required to treat underlying pathology, such as rotator cuff or biceps tendinopathy 4.

Awareness and Knowledge of SIRVA

  • Healthcare practitioner knowledge of SIRVA is poor, with mean scores of 55% 5.
  • Non-immunising healthcare practitioners scored significantly higher than immunising practitioners for anatomy and safe injecting knowledge 5.
  • Greater education and awareness of SIRVA is needed in all healthcare disciplines 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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