What is the recommended short-term duration for using Quetiapine (quetiapine) to treat Hallucinogen Persisting Perception Disorder (HPPD)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
DS

Dainyal Siddiqui, MD

Internal Medicine

MJ

Manuel Jimenez, MD

Cardiology

FP

Franz Pierre-Louis, MD

Infectious Disease

Article Review Status
Submitted
Under Review
Approved

Last updated: March 28, 2025 • View editorial policy

From the Research

Quetiapine should be used for the shortest duration possible, ideally 2-4 weeks, for the treatment of Hallucinogen Persisting Perception Disorder (HPPD), due to the lack of strong evidence supporting its long-term efficacy and concerns about potential side effects 1. The recommended short-term duration for using Quetiapine to treat HPPD is based on the need to balance the potential benefits of treatment with the risks of prolonged use, including metabolic effects, sedation, and potential for dependence 2, 3. Some key points to consider when using Quetiapine for HPPD include:

  • Starting with the lowest effective dose, often 25-50mg at bedtime, and tapering off gradually rather than stopping abruptly 4
  • Close monitoring by a psychiatrist to evaluate the effectiveness of treatment and adjust as needed 5
  • Considering alternative approaches, such as lamotrigine, benzodiazepines (short-term), or non-medication therapies like CBT, for longer-term management 2, 1 It's essential to prioritize the patient's safety and well-being when using Quetiapine for HPPD, and to carefully weigh the potential benefits and risks of treatment 3, 1.

References

Related Questions

What is the dose of Quetiapine (Atypical Antipsychotic) for Hallucinogen Persisting Perception Disorder (HPPD)?
What are the alternative PRNs (as needed) for Quetiapine (quetiaparm) if it causes panic attacks in patients with Hallucinogen Persisting Perception Disorder (HPPD)?
What is the differential diagnosis (DDX) for a patient presenting with 2 days of left lower quadrant pain, bloating, and nausea after alcohol intake?
What is the differential diagnosis for elevated Carcinoembryonic Antigen (CEA) levels?
Which Selective Serotonin Reuptake Inhibitor (SSRI) has the best efficacy?
What is the normal level of Carcinoembryonic Antigen (CEA)?
What are the main differences between olanzapine (atypical antipsychotic) and risperidone (atypical antipsychotic) in terms of their pharmacological profiles and side effect profiles?
What is the relationship between Carcinoembryonic Antigen (CEA) and teratoma?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Ask a new Question. Chat with the Guidelines