Incidence of ATTR Amyloidosis
The question asks about ATTR amyloidosis, but the provided evidence exclusively addresses AL (light chain) and AA (amyloid A) amyloidosis, with no specific incidence data for ATTR amyloidosis available in these sources.
Important Clarification
The evidence provided does not contain incidence data for ATTR (transthyretin) amyloidosis, which is a distinct entity from:
- AL amyloidosis (light chain amyloidosis associated with plasma cell disorders) 1
- AA amyloidosis (reactive amyloidosis secondary to chronic inflammatory conditions) 2, 3
Available Incidence Data from Evidence (Not ATTR)
AL Amyloidosis Incidence
The incidence of AL amyloidosis ranges from 3 to 13 cases per million population per year across Western countries 1:
- United States: 8-14 cases per million per year 1
- United Kingdom: 3 cases per million per year 1
- Sweden: 3.2 cases per million per year 1, 4
- Netherlands: 6 cases per million per year 1
- Italy: 13.29 cases per million per year 1
- Regional estimates (Minnesota, Florence, Limousine): approximately 12 cases per million per year 1
AA Amyloidosis Incidence
AA amyloidosis has an estimated incidence of approximately 1-2 cases per million population per year 4, 2:
- Sweden: approximately 2.0 cases per million per year (when accounting for rheumatoid arthritis-related deaths) 4
- France: estimated 500-700 total cases in the entire population 3
ATTR Amyloidosis Context (Limited Data Available)
The only reference to ATTR in the evidence indicates:
- Variant (hereditary) ATTR: estimated incidence of 0.3 cases per million per year 5
- Wild-type ATTR: prevalence estimate of 155-191 cases per million persons (not incidence) 5
Critical Caveat
ATTR amyloidosis is fundamentally different from AL and AA amyloidosis in pathophysiology, clinical presentation, and epidemiology 6, 7. ATTR more commonly affects the heart, peripheral nerves, and musculoskeletal system, whereas AL amyloidosis predominantly affects kidneys and heart 6. The incidence data for AL and AA amyloidosis cannot be extrapolated to estimate ATTR incidence.