From the Guidelines
Kratom use is associated with significant adverse effects and should be discontinued due to its potential for serious harm, including seizures, liver damage, withdrawal symptoms, and even death. This plant-derived substance contains compounds (mitragynine and 7-hydroxymitragynine) that interact with opioid receptors in the brain, producing effects ranging from stimulation at low doses to sedation and pain relief at higher doses 1. The FDA has not approved kratom for any medical use and has issued multiple warnings about its potential dangers, citing opioid- and stimulant-like properties, as well as the risk of withdrawal syndrome if taken in high doses (more than 5 to 15 g per day) 1.
Key Considerations
- Kratom has been linked to serious side effects, including seizures, liver damage, withdrawal symptoms, and even death in some cases 1.
- The risk of dependence and addiction increases with regular use, and kratom products lack standardization, meaning potency and purity can vary widely between products.
- People with pre-existing health conditions, those taking medications, pregnant women, and individuals with substance use disorders should be particularly cautious when considering kratom use.
- If someone is considering using kratom for pain management or other conditions, they should first consult with a healthcare provider about FDA-approved treatments with established safety profiles instead of self-medicating with this unregulated substance.
Recommendations
- Discontinue kratom use due to its potential for serious adverse effects 1.
- Consider alternative, FDA-approved treatments for pain management and other conditions.
- Consult with a healthcare provider before using any dietary supplements, especially those with potential interactions or adverse effects.