From the Guidelines

Soolantra (ivermectin) is effective for treating rosacea, particularly for inflammatory lesions.

A 12-week pilot study of 20 subjects with IGA scores ≥ 3 demonstrated clinical improvement with in vivo reduction of demodex mite density and improved cutaneous inflammatory markers with once-daily ivermectin cream 1% 1.
Two parallel 12-week, double-blind, randomized controlled trials of 683 and 688 adults showed that ivermectin 1% cream was superior to vehicle in achieving treatment success, defined by IGA as “clear” (0) or “almost clear” (1) at 12 weeks, with 38.4% and 40.1% of subjects achieving treatment success compared to 11.6% and 18.8% in the vehicle groups 1.
A head-to-head comparison study found that ivermectin 1% cream was superior to metronidazole 0.75% cream in reducing lesion counts and achieving IGA ratings of clear (0) or almost clear (1) 1.
Ivermectin 1% cream is considered a first-line treatment for moderate to severe rosacea, particularly for inflammatory papules and pustules 1.

The recommended dosage of ivermectin cream is 1% applied once daily.
Treatment duration can vary, but studies have shown efficacy with 12-week treatment periods.
Ivermectin cream has been shown to be well-tolerated, with fewer adverse effects compared to vehicle 1.

From the Research

Soolantra (ivermectin 1% cream) has been shown to be effective in treating inflammatory lesions of rosacea, with improvements in symptoms and health-related quality of life 2.
The treatment has been found to be more effective than metronidazole 0.75% cream in reducing inflammatory lesion counts and improving health-related quality of life 2.
Ivermectin has anti-inflammatory and anti-parasitic properties, which contribute to its efficacy in treating rosacea by killing Demodex mites and reducing inflammation 3.

Phase III trials have demonstrated the efficacy of ivermectin 1% cream in treating moderate to severe papulopustular rosacea, with significant improvements in inflammatory lesion counts and health-related quality of life 2.
A retrospective pilot study found that once-daily topical treatment with ivermectin 1% cream improved subjective symptoms, skin findings, and ocular changes in patients with rosacea, with no side effects observed 4.
A real-life experience study found that ivermectin 1% cream was effective and well-tolerated in patients with almost clear to severe rosacea, with significant decreases in inflammatory lesion counts and improvement in disease severity 5.

Ivermectin's anti-parasitic activity kills Demodex mites, which are thought to contribute to the development of rosacea 3.
The treatment's anti-inflammatory effects reduce inflammation and improve symptoms of rosacea 3.
Ivermectin 1% cream has been found to be effective in treating various phenotypes of rosacea, including erythematotelangiectatic, papulopustular, and phymatous rosacea 6.