Does Hydrochlorothiazide (HCTZ) (a diuretic) cause weight loss?

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From the FDA Drug Label

CLINICAL PHARMACOLOGY Hydrochlorothiazide blocks the reabsorption of sodium and chloride ions, and it thereby increases the quantity of sodium traversing the distal tubule and the volume of water excreted. The answer is: Yes, Hydrochlorothiazide (HCTZ) can cause weight loss due to increased water excretion.

  • Key points:
    • Increased water excretion leads to weight loss
    • This effect is a result of the drug's mechanism of action, which involves blocking sodium and chloride reabsorption in the kidneys 1

References

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