What causes palpitations with Nicotinamide adenodesyl (NAD+) injections?

NAD+ injections can cause palpitations primarily due to their vasodilatory effects and impact on the cardiovascular system. When NAD+ is administered via injection, it can cause rapid peripheral vasodilation, leading to a sudden drop in blood pressure. In response, your heart may compensate by beating faster or more forcefully, which you experience as palpitations. Additionally, NAD+ plays a role in cellular energy production and can directly affect cardiac cells, potentially altering heart rhythm. The rapid introduction of NAD+ into the bloodstream may also trigger a temporary autonomic nervous system response, causing fluctuations in heart rate. These effects are typically transient and resolve as your body metabolizes the NAD+. The risk of palpitations may be higher with rapid administration or higher doses. If you experience severe or persistent palpitations with NAD+ injections, you should consult a healthcare provider, as this could indicate an adverse reaction requiring medical attention or adjustment of your treatment protocol.