From the Guidelines
Bactrim (Trimethoprim/Sulfamethoxazole) is an effective treatment option for sinusitis, particularly for patients with severe symptoms or those who are allergic to penicillins, and should be considered as an alternative to first-line antibiotics such as amoxicillin or doxycycline 1, 2.
Treatment Approach
When considering Bactrim for sinusitis treatment, it's essential to note that:
- The typical adult dosage for acute sinusitis is Bactrim DS (double strength) taken as one tablet (800mg sulfamethoxazole/160mg trimethoprim) twice daily for 10-14 days.
- Bactrim works by inhibiting bacterial synthesis of folic acid, which bacteria need to survive and multiply.
- This antibiotic is particularly useful for patients who are allergic to penicillins or when first-line antibiotics have failed.
Key Considerations
Some key points to consider when treating sinusitis with Bactrim include:
- Symptomatic treatment or reassurance is the preferred initial approach for patients with mild or moderate symptoms 1.
- Patients with severe or persistent moderate symptoms and specific findings of bacterial rhinosinusitis should be treated with antibiotics, with narrow-spectrum agents such as amoxicillin, doxycycline, and trimethoprim-sulfamethoxazole being reasonable first-line agents 2.
- Side effects of Bactrim may include rash, nausea, diarrhea, and sun sensitivity, and patients should be advised to drink plenty of fluids to prevent kidney complications and to contact their healthcare provider if they develop severe side effects.