Sodium Content in Zosyn (Piperacillin/Tazobactam)
Zosyn contains 2.35 mEq (54 mg) of sodium per gram of piperacillin component. 1
Specific Sodium Content by Dose Strength
3.375 g dose (3 g piperacillin + 0.375 g tazobactam): Contains approximately 7.05 mEq (162 mg) of sodium 1
4.5 g dose (4 g piperacillin + 0.5 g tazobactam): Contains approximately 9.4 mEq (216 mg) of sodium 1
Clinical Implications for Maximum Daily Dosing
The highest recommended adult dosage is 4.5 g IV every 6 hours, resulting in a maximum daily dose of 18 g of piperacillin component 2
At maximum dosing (18 g piperacillin per day), the total daily sodium load is approximately 42.3 mEq (972 mg) 1
For patients receiving the standard severe infection regimen of 3.375 g every 6 hours, the daily sodium load is approximately 28.2 mEq (648 mg) 2, 1
Important Considerations for Sodium-Restricted Patients
Patients with heart failure, renal impairment, or those on sodium-restricted diets should have their total sodium intake monitored when receiving Zosyn at high doses 1
The sodium content should be factored into the patient's total daily sodium allowance, particularly in critically ill patients receiving multiple sodium-containing intravenous medications 1
Renal dose adjustments will reduce the total daily sodium load proportionally, as the dosing frequency decreases with declining creatinine clearance 3