From the FDA Drug Label
In the event of overdose, consider standard measures to remove any unabsorbed drug. Symptomatic and supportive treatment is recommended. Desloratadine and 3-hydroxydesloratadine are not eliminated by hemodialysis
The treatment for Desloratadine (Clarinex) overdose is symptomatic and supportive treatment. Standard measures should be taken to remove any unabsorbed drug. It is also important to note that Desloratadine and its metabolite are not eliminated by hemodialysis 1.