Sodium Content of Zosyn (Piperacillin/Tazobactam)
Zosyn contains 2.35 mEq (54 mg) of sodium per gram of piperacillin in the combination product. 1
Specific Sodium Content by Vial Size
The FDA-approved drug label provides exact sodium content for each formulation:
2.25 g vial (2 g piperacillin/0.25 g tazobactam): Contains 4.7 mEq (108 mg) of sodium 1
3.375 g vial (3 g piperacillin/0.375 g tazobactam): Contains 7.05 mEq (162 mg) of sodium 1
4.5 g vial (4 g piperacillin/0.5 g tazobactam): Contains 9.4 mEq (216 mg) of sodium 1
Clinical Implications for Daily Sodium Load
When calculating total daily sodium intake, the dosing frequency significantly impacts sodium burden:
Standard dosing of 3.375 g IV every 6 hours (4 doses/day) delivers 28.2 mEq (648 mg) of sodium daily 1
High-dose regimen of 4.5 g IV every 6 hours (4 doses/day) delivers 37.6 mEq (864 mg) of sodium daily 2, 3, 1
Maximum recommended dosing of 4.5 g IV every 6 hours provides the highest sodium load at nearly 38 mEq per day 2, 3
Important Considerations
This sodium content is clinically relevant for patients with:
- Heart failure requiring strict sodium restriction
- Chronic kidney disease with fluid overload
- Cirrhosis with ascites
- Hypertension requiring tight sodium control
The sodium load from Zosyn should be factored into the patient's total daily sodium allowance, particularly when using higher doses (4.5 g every 6 hours) recommended for serious infections like nosocomial pneumonia, ventilator-associated pneumonia, or infections caused by Pseudomonas aeruginosa. 2, 3