What is the differential diagnosis (Ddx) for a bilateral hand rash?

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Last updated: March 28, 2025 • View editorial policy

Differential Diagnosis for Bilateral Hand Rash

  • Single Most Likely Diagnosis

    • Contact Dermatitis: This is the most likely diagnosis due to the common exposure of hands to various irritants and allergens, leading to an immune response and subsequent rash.
  • Other Likely Diagnoses

    • Eczema (Atopic Dermatitis): A common skin condition characterized by dry, itchy, and inflamed skin, often affecting the hands.
    • Psoriasis: An autoimmune condition that can cause red, scaly patches on the hands, especially on the palms.
    • Dyshidrotic Eczema: A type of eczema that specifically affects the hands and feet, causing small, itchy blisters.
  • Do Not Miss Diagnoses

    • Toxic Epidermal Necrolysis (TEN): A life-threatening condition that can cause widespread skin necrosis and detachment, often triggered by medications or infections.
    • Staphylococcal Scalded Skin Syndrome (SSSS): A condition caused by staphylococcal toxins that can lead to widespread skin blistering and peeling.
    • Keratomycosis (Fungal Infection): A fungal infection that can cause a severe and potentially sight-threatening infection if left untreated.
  • Rare Diagnoses

    • Pompholyx: A rare condition characterized by the formation of small, itchy blisters on the hands and feet.
    • Keratoderma: A group of rare genetic disorders that can cause thickening of the skin on the hands and feet.
    • Leopard Syndrome: A rare genetic disorder that can cause skin, hair, and eye abnormalities, including a rash on the hands.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.