What is the relationship between D-dimer (D-dimer) levels and plasma viscosity in patients with hypertension?

D-dimer levels and plasma viscosity are positively correlated in hypertensive patients, with both markers often elevated in this population. D-dimer, a fibrin degradation product indicating active coagulation, tends to increase in hypertensive patients due to endothelial dysfunction and a prothrombotic state. Similarly, plasma viscosity, which measures blood's resistance to flow, is frequently elevated in hypertension due to increased fibrinogen levels, red blood cell aggregation, and inflammatory processes. This relationship is clinically significant because elevated levels of both markers suggest increased cardiovascular risk in hypertensive patients. When managing hypertensive patients with elevated D-dimer and plasma viscosity, controlling blood pressure with appropriate antihypertensive medications (such as ACE inhibitors, ARBs, calcium channel blockers, or diuretics) is essential. Additionally, addressing modifiable risk factors like smoking cessation, weight management, and increasing physical activity can help reduce both markers. In some cases, antiplatelet therapy like low-dose aspirin (75-100mg daily) might be considered for high-risk patients. Regular monitoring of these parameters, especially in patients with uncontrolled hypertension or additional cardiovascular risk factors, can help guide treatment adjustments and potentially prevent thrombotic complications.