From the Research
You should not prescribe Ticagrelor (TPX) to someone with a penicillin allergy, as TPX is not a penicillin derivative, but the concern lies in the potential for cross-reactivity or mislabeling of the allergy. However, Ticagrelor is an antiplatelet medication, not an antibiotic, and its use is not directly related to penicillin allergy. The provided evidence does not directly address the use of Ticagrelor in patients with penicillin allergies, but it discusses the importance of penicillin allergy testing and the use of alternative antibiotics in patients with penicillin allergies 1. When considering the use of any medication in a patient with a reported allergy, it's essential to evaluate the severity and type of the previous reaction, as some patients may tolerate certain medications under careful supervision, but this requires specialist evaluation. In the context of Ticagrelor, which is used for preventing thrombotic events, the primary concern would be ensuring the patient's safety regarding their allergy status, but this is more relevant to antibiotics rather than antiplatelet agents. Given the information provided and the nature of Ticagrelor, the decision to prescribe Ticagrelor should be based on its indications and the patient's cardiovascular risk factors rather than concerns about penicillin allergy. It's crucial to note that the evidence provided focuses on antibiotic use and penicillin allergy, which is not directly applicable to the use of Ticagrelor, an antiplatelet agent 2, 3, 4, 5. Therefore, in clinical practice, the use of Ticagrelor would be guided by its approved indications and the patient's specific cardiovascular needs, rather than concerns related to penicillin allergy.