From the Research
Effect of a 450mg Dose of Trazodone
- The provided studies do not specifically mention the effects of a 450mg dose of trazodone 1, 2, 3, 4, 5.
- However, the studies suggest that trazodone is usually well tolerated at doses ranging from 150-300 mg/day 2, 5.
- Higher doses of up to 600 mg/day are tolerated by younger patients, but the maximum tolerated doses in the elderly are 300 to 400 mg/day 3.
- The side effects of trazodone are dose-dependent, and the most common side effects include drowsiness, headache, dizziness, and xerostomia 1, 2, 4, 5.
- It is worth noting that trazodone may be associated with rare but serious side effects, such as orthostatic hypotension, QT interval prolongation, cardiac arrhythmias, and priapism, especially at higher doses or in vulnerable populations 3, 4, 5.
Therapeutic Use of Trazodone
- Trazodone is an established antidepressant that is efficacious for the treatment of a broad array of depressive symptoms, including insomnia 1, 2, 5.
- It has a favorable profile for the treatment of depression, with a low risk of anticholinergic side effects, weight gain, and sexual side effects 2, 5.
- Trazodone may be helpful for patients with major depression and comorbid insomnia, anxiety, or psychomotor agitation 2, 5.
- The medication has also been used as a hypnotic for psychotropic-induced or other insomnias with some success 3, 4.