From the Research
Supplemental iron typically increases serum iron levels within 1-2 weeks of starting therapy, though it may take 3-6 months to fully replenish iron stores in cases of significant deficiency. For oral iron supplements, absorption is best on an empty stomach with vitamin C to enhance uptake 1. The most recent and highest quality study suggests that oral iron doses of 60-120 mg given on alternate days may be an optimal regimen for increasing serum iron levels in cases of iron deficiency 1.
Key Considerations
- The severity of deficiency, type and dose of supplement used, individual absorption capacity, and underlying conditions affecting iron metabolism all impact the speed of response to supplemental iron.
- Regular monitoring of iron levels, ferritin, and complete blood counts is crucial to assess response to supplementation and adjust dosing as needed.
- While serum iron may increase relatively quickly, improvements in symptoms like fatigue or shortness of breath may take longer as hemoglobin production requires additional time.
Optimal Dosing Regimen
- Morning doses of 60-120 mg iron as a ferrous salt given with ascorbic acid on alternate days may be an optimal oral dosing regimen for women with iron-deficiency and mild IDA 1.
- This regimen may increase iron absorption and reduce side effects compared to daily dosing regimens.
Important Factors
- Individual factors such as absorption capacity and underlying health conditions can impact the effectiveness of supplemental iron.
- Regular follow-up and monitoring are essential to ensure the chosen regimen is effective and to make adjustments as needed.