From the Research
Hydroxyzine can be safely taken by individuals with a COVID-19 vaccine (Pfizer-BioNTech) allergy, as there is no known interaction or cross-reactivity between hydroxyzine and the vaccine components. If you've had an allergic reaction to the Pfizer COVID-19 vaccine, you can continue using hydroxyzine as prescribed, as it is an antihistamine that works by blocking H1 receptors and may actually help manage symptoms of mild allergic reactions 1. However, if you experienced a severe allergic reaction (anaphylaxis) to the Pfizer vaccine, hydroxyzine alone would be insufficient treatment - you would need immediate medical attention and epinephrine. The allergic reactions to mRNA vaccines are typically attributed to polyethylene glycol (PEG) in the lipid nanoparticle delivery system, which is not present in hydroxyzine 2.
Some key points to consider:
- Hydroxyzine is typically dosed at 25-50mg every 6-8 hours for adults
- Allergic reactions to mRNA vaccines are rare, with a rate of 11.1 per million doses administered for anaphylaxis 1
- The European Academy of Allergy and Clinical Immunology (EAACI) states that mild and moderate allergic patients should not be excluded from the vaccine, as the benefit of vaccination clearly outweighs the risk of severe COVID-19 development 3
- If you're concerned about taking hydroxyzine after a vaccine reaction, consult your healthcare provider, but there is no medical reason to avoid this medication based solely on having a Pfizer vaccine allergy 4
It's essential to note that while hydroxyzine can be safely taken, it's crucial to prioritize caution and consult with a healthcare provider if you've experienced any severe allergic reactions to the Pfizer vaccine. Additionally, vaccine locations should have the necessary supplies available to manage anaphylaxis and implement post-vaccination observation periods 1.