From the FDA Drug Label
The provided drug labels do not explicitly state contraindications for Solumedrol (Methylprednisolone). The FDA drug label does not answer the question.
From the Research
Solumedrol (methylprednisolone sodium succinate) is contraindicated in patients with systemic fungal infections, known hypersensitivity to methylprednisolone, and those receiving live or live-attenuated vaccines, due to its immunosuppressive effects. The use of Solumedrol in these scenarios can worsen infections, lead to allergic reactions, or result in vaccine-related infections 1.
Key Contraindications
- Systemic fungal infections: Solumedrol can suppress immune function, leading to worse outcomes in patients with fungal infections such as aspergillosis, candidemia, and mucormycosis 1.
- Known hypersensitivity: Patients with a known hypersensitivity to methylprednisolone or any components of the formulation should avoid Solumedrol due to the risk of allergic reactions.
- Live or live-attenuated vaccines: The immunosuppressive effects of Solumedrol may lead to vaccine-related infections, making it contraindicated in patients receiving these types of vaccines.
Additional Considerations
- Active tuberculosis, herpes simplex of the eye, recent myocardial infarction, heart failure, hypertension, diabetes mellitus, osteoporosis, peptic ulcer disease, and psychiatric disorders: Solumedrol may exacerbate these conditions, and caution is warranted when using the medication in patients with these comorbidities.
- Pregnancy: Solumedrol should be used with extreme caution during pregnancy, particularly in the first trimester, as corticosteroids can cross the placental barrier and potentially affect fetal development.
- Cerebral malaria: Systemic corticosteroids like Solumedrol are contraindicated in patients with cerebral malaria, as they can worsen outcomes.
The mechanism behind these contraindications relates to Solumedrol's potent anti-inflammatory and immunosuppressive effects, which while therapeutic in many conditions, can worsen infections, metabolic disorders, and certain disease states 1.