Can hypermagnesemia cause palpitations?

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Last updated: March 28, 2025View editorial policy

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From the Guidelines

Yes, hypermagnesemia can cause palpitations, as extremely high serum magnesium levels may produce cardiac arrhythmias. Hypermagnesemia is defined as a serum magnesium concentration >2.2 mEq/L, and it can occur in individuals with kidney dysfunction or those taking excessive amounts of magnesium-containing medications or supplements 1.

Symptoms of Hypermagnesemia

  • Muscular weakness
  • Paralysis
  • Ataxia
  • Drowsiness
  • Confusion
  • Vasodilation and hypotension
  • Bradycardia
  • Cardiac arrhythmias
  • Hypoventilation
  • Cardiorespiratory arrest

If you're experiencing palpitations and suspect high magnesium levels, you should discontinue any magnesium supplements and seek medical attention for proper evaluation. Treatment typically involves stopping magnesium intake, and in severe cases, may require calcium gluconate administration or dialysis, as suggested by the American Heart Association guidelines 1. Magnesium plays a crucial role in cardiac function by regulating electrical impulses in the heart, which explains why both high and low levels can disrupt normal heart rhythm. It is essential to seek medical attention immediately if you are experiencing symptoms of hypermagnesemia, as prompt treatment can help prevent serious complications, including cardiac arrest.

From the Research

Hypermagnesemia and Palpitations

  • Hypermagnesemia is a condition characterized by elevated magnesium concentrations in the blood, which can lead to various complications, including cardiovascular issues 2.
  • Magnesium plays a crucial role in cardiac excitability, and abnormalities in magnesium levels can affect heart function 2, 3.
  • While hypomagnesemia is often associated with cardiac arrhythmias, hypermagnesemia can also have adverse effects on the cardiovascular system, including respiratory and cardiovascular negative outcomes 2.
  • However, there is limited direct evidence linking hypermagnesemia to palpitations specifically.
  • Studies have shown that magnesium is important in cardiac arrhythmias, and intravenous magnesium can be used to treat certain types of arrhythmias, such as Torsade de pointes tachycardias and digitalis toxicity induced tachyarrhythmias 3.
  • Additionally, oral magnesium has been used to reduce the incidence of extrasystoles and symptoms in patients with symptomatic extrasystoles 3.
  • It is essential to note that hypermagnesemia can occur in patients with impaired renal function or those receiving magnesium-containing medications or supplements, and prompt identification and management are crucial to prevent complications 2, 4, 5, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Hypermagnesemia in Clinical Practice.

Medicina (Kaunas, Lithuania), 2023

Research

[Significance of magnesium in cardiac arrhythmias].

Wiener medizinische Wochenschrift (1946), 2000

Research

Magnesium and Dialysis: The Neglected Cation.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015

Research

Daily magnesium intake and hypermagnesemia in hemodialysis patients with chronic kidney disease.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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