Initial Management of Patellofemoral Pain
Start all patients with knee-targeted quadriceps exercise therapy combined with patient education—this is the foundation of treatment supported by high certainty evidence for short-term pain reduction and moderate certainty evidence for functional improvement. 1
Primary Treatment: Exercise Therapy
Knee-Targeted Quadriceps Strengthening
- Implement progressive quadriceps strengthening in both open and closed chain exercises as the cornerstone intervention (SMD 1.16 for pain reduction, 95% CI 0.66-1.66). 1
- Focus on strengthening the quadriceps with the knee extended to reduce patellofemoral pressure. 2
- Progress loading systematically based on symptom severity and irritability. 2
- Patients often experience rapid improvement—quadriceps strengthening can help "overnight, quite literally" according to patient reports. 1
Hip-Targeted Exercise Addition
- Add hip abductor and hip extensor strengthening exercises (side-lying leg raises, clamshells) when patients demonstrate poor tolerance to loaded knee flexion. 2, 3
- Combined hip and knee strengthening produces better outcomes than knee exercises alone. 2
- Hip-targeted exercises are particularly beneficial for patients who cannot tolerate initial knee loading. 2
Essential Education Component
Education must underpin every intervention from the first visit. 2, 3
- Explain that pain does not necessarily correlate with tissue damage—this reduces fear and improves compliance. 2, 3
- Provide clear rationale for the specific exercise prescription to build patient confidence. 2
- Set realistic expectations: over 50% of patients report persistent pain beyond 5 years if treatment is inadequate, making early aggressive conservative management critical. 1, 3
- Emphasize activity modification while maintaining function—patients need to understand how to adjust rather than avoid activities. 3, 4
Initial Assessment Priorities
Before prescribing treatment, evaluate these specific factors:
Subjective Assessment
- Pain levels and tolerance during functional activities (squatting, stairs, running). 2, 3
- Fear of movement and self-efficacy related to symptoms. 2, 3
- Impact on daily life, work demands, and recreational activities. 3
- Patient expectations and perceived joint resilience. 2
Objective Assessment
- Hip and knee strength testing, particularly quadriceps and hip abductors. 3
- Movement pattern analysis during functional tasks. 3
- Tissue tolerance to load. 3
- Range of motion and muscle length, especially lateral structures. 5
Supporting Interventions (Add Based on Specific Findings)
Prefabricated Foot Orthoses
- Prescribe when patients respond favorably to treatment direction tests (immediate symptom reduction with orthotic positioning). 2, 3
- Most beneficial in the short term and can provide "instant treatment" with minimal compliance burden. 1, 3
- Do not add orthoses routinely—they show no additional benefit when combined with comprehensive exercise therapy unless specifically indicated. 1
Manual Therapy
- Use soft tissue mobilization of lateral retinacular structures and iliotibial band when rehabilitation is hindered by elevated symptom severity or high fear of movement (SMD 2.30 for function improvement, 95% CI 1.60-3.00). 1, 3
- Manual therapy facilitates exercise therapy but should not replace it. 3
Patellar Taping
- Apply taping techniques when symptom severity or fear of movement limits exercise participation. 2, 3
- Taping is an adjunct to facilitate exercise, not a standalone treatment. 3
Movement/Running Retraining
- Consider for patients with task-specific biomechanical issues identified during movement analysis. 2
- Gait retraining addresses movement-related etiology directly. 5
Pharmacologic Options (Adjunctive Only)
- Acetaminophen up to 4,000 mg/day can be used initially for its favorable safety profile. 2
- Topical NSAIDs provide local anti-inflammatory effects with fewer systemic side effects as an alternative first-line option. 2
Treatment Timeline and Reassessment
- Reassess after a minimum of 6 weeks of consistent treatment. 2, 3
- If outcomes are unfavorable, revisit assessment findings to ensure interventions align with initial clinical reasoning. 2
- Consider imaging (radiographs or MRI) only after 6-8 weeks of failed conservative therapy to rule out other pathologies. 3
Critical Pitfalls to Avoid
- Do not focus solely on knee exercises without addressing hip strength—this is a common error that limits outcomes. 3
- Do not over-rely on passive treatments (taping, manual therapy, orthoses) at the expense of active exercise therapy. 3, 4
- Do not order imaging prematurely—overemphasis on imaging without adequate trial of conservative management delays effective treatment. 3
- Do not prescribe hyaluronic acid injections—these demonstrate non-efficacy compared to exercise therapy alone. 1
- Do not use dry needling as a standalone treatment—it shows non-efficacy compared to sham needling. 1
Algorithm Summary
- Begin immediately with knee-targeted quadriceps strengthening + education for all patients. 1, 2
- Add hip strengthening if poor tolerance to loaded knee flexion. 2
- Add prefabricated foot orthoses only if favorable response to treatment direction tests. 2, 3
- Add manual therapy and/or taping only if high symptom severity or fear of movement limits exercise participation. 2, 3
- Add movement retraining only if task-specific biomechanical issues identified. 2
- Reassess at 6 weeks minimum; if no improvement, revisit assessment and consider imaging. 2, 3