From the Research
Significance of Elevated Anti-Thyroglobulin (Anti-Tg) Antibodies
Elevated Anti-Thyroglobulin (Anti-Tg) antibodies have been found to be significant in various studies related to thyroid disorders. The key findings are:
- Elevated Anti-Tg antibodies are associated with an increased risk of progression from subclinical to overt hypothyroidism in patients with Hashimoto's thyroiditis 1.
- High titers of IgG1 and IgG2 Anti-Tg antibodies imply the possibility of development from subclinical hypothyroidism to overt hypothyroidism 1.
- Elevated Anti-Tg antibodies are also associated with symptom burden in patients with Hashimoto's thyroiditis, suggesting a role of thyroid autoimmunity in clinical manifestations of the disease 2.
- In patients with differentiated thyroid carcinoma, persistently elevated Anti-Tg antibody levels are prognostic of future recurrences 3.
- Elevated Anti-Tg antibodies can interfere with thyroglobulin (Tg) determination, and their measurement can be useful in the follow-up of patients with differentiated thyroid carcinoma 4, 3.
Clinical Implications
The clinical implications of elevated Anti-Tg antibodies are:
- They may indicate an increased risk of progression to overt hypothyroidism in patients with subclinical hypothyroidism 1, 5.
- They may be associated with symptom burden in patients with Hashimoto's thyroiditis 2.
- They can be used as a tumor marker in the follow-up of patients with differentiated thyroid carcinoma 4, 3.
- Their measurement can be useful in establishing the accuracy of Tg as a tumor marker 3.
Key Findings
The key findings related to elevated Anti-Tg antibodies are:
- Elevated Anti-Tg antibodies are associated with an increased risk of progression to overt hypothyroidism and symptom burden in patients with Hashimoto's thyroiditis 1, 2.
- They can be used as a tumor marker in the follow-up of patients with differentiated thyroid carcinoma 4, 3.
- Their measurement can be useful in establishing the accuracy of Tg as a tumor marker 3.
- Elevated Anti-Tg antibodies may indicate an increased risk of recurrence in patients with differentiated thyroid carcinoma 4, 3.