From the Research
Cefuroxime Dosage for UTI
- The standard dosage of cefuroxime for urinary tract infections (UTIs) is 250 mg twice daily 1.
- However, some studies have used different dosages, such as 500 mg twice daily or 250 mg once daily 2, 3.
- The effectiveness of cefuroxime in treating UTIs has been demonstrated in several studies, with cure rates ranging from 78% to 93% 4, 2.
Comparison of TID and BID Dosage
- There is limited information available on the comparison of 500 mg cefuroxime TID (three times a day) versus BID (twice a day) for the treatment of UTIs.
- One study compared the effectiveness of cefuroxime axetil 250 mg BID with amoxicillin/clavulanate 500 mg TID in the treatment of patients with secondary bacterial infections of acute bronchitis, and found that cefuroxime axetil was as effective as amoxicillin/clavulanate but produced fewer gastrointestinal adverse events 5.
- However, this study did not specifically address the comparison of TID and BID dosages of cefuroxime for UTIs.
Safety and Efficacy
- Cefuroxime has been shown to be generally safe and well-tolerated, with mild and transient adverse reactions, such as gastrointestinal disturbances, being the most common 1, 2.
- The efficacy of cefuroxime in treating UTIs has been demonstrated in several studies, with cure rates ranging from 78% to 93% 4, 2.
- However, one study found that cefuroxime axetil had a higher relapse rate when tested 6 weeks after the start of treatment compared to amoxycillin, which may be due to variable bioavailability 3.