From the Research
I strongly advise against combining ginseng and lamotrigine without medical supervision due to the potential for serious interactions, including the risk of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, which has a mortality rate of 10-40%. The concern stems from ginseng's ability to affect certain liver enzymes that metabolize medications, potentially changing lamotrigine blood levels 1. If you're taking lamotrigine, consult your healthcare provider before starting any herbal supplements, including ginseng. Your doctor might need to monitor your lamotrigine levels more closely if you use both substances together. Some key points to consider when combining ginseng and lamotrigine include:
- The potential for ginseng to inhibit the uridine diphosphate glucuronosyltransferase 2B7 enzyme, leading to increased lamotrigine levels 1
- The risk of DRESS syndrome, a potentially life-threatening condition characterized by fever, lymphadenopathy, diffuse maculopapular rash, multivisceral involvement, eosinophilia, and atypical lymphocytes 1
- The importance of informing all healthcare providers about all medications and supplements you take, including herbal products, to avoid potentially harmful interactions 2
- The need for medical supervision when combining ginseng and lamotrigine to minimize the risk of adverse interactions and ensure safe treatment. It is essential to prioritize caution when combining herbal supplements like ginseng with prescription medications like lamotrigine, as the potential risks can be significant. Always consult with a healthcare professional before starting any new supplements or medications, especially if you are already taking prescription medications. By taking a cautious approach and consulting with a healthcare professional, you can minimize the risk of adverse interactions and ensure safe treatment.