Recommended Volume for Deltoid IM Injection
The maximum recommended volume for a deltoid intramuscular injection in adults is 0.5 mL per dose. 1
Standard Volume Guidelines
For adults and children ≥36 months (≥3 years): The approved dose volume for intramuscular vaccines is 0.5 mL per dose when administered in the deltoid muscle 1
For infants and younger children (6-35 months): Vaccine volumes may be either 0.25 mL or 0.5 mL depending on the specific vaccine formulation, but these should be administered in the anterolateral thigh rather than the deltoid 1
Critical Administration Points
The deltoid muscle is the preferred site for IM injections in adults and older children, while infants and younger children should receive injections in the anterolateral thigh 1, 2
Use a 1 to 1½ inch, 22-25 gauge needle for deltoid injections in adults and adolescents to ensure proper muscle penetration 2, 3
Insert the needle at a 90-degree angle to reach the muscle mass adequately 2, 3
Common Pitfalls to Avoid
Never split a 0.5 mL dose into two 0.25 mL doses due to safety concerns regarding sterility and compliance with package labeling 1
Administering volumes smaller than recommended can result in inadequate protection and should not be counted as valid doses unless serologic testing confirms adequate response 1
Using larger than recommended doses can be hazardous due to excessive local or systemic concentrations of antigens 1
Avoid the buttock for routine IM injections due to risk of sciatic nerve injury and decreased vaccine immunogenicity 1, 2, 4