From the Research
DIM (diindolylmethane) helps with estrogen clearance by promoting the metabolism of estrogen through healthier pathways, specifically enhancing the 2-hydroxylation pathway of estrogen metabolism, as demonstrated in a recent study published in 2024 1. The mechanism of DIM in estrogen clearance involves supporting phase 1 liver detoxification, which leads to the production of less biologically active and potentially safer estrogen metabolites compared to the 16-hydroxylation pathway. Key points to consider when using DIM for estrogen clearance include:
- A typical recommended dose ranges from 100-300mg daily, taken with food to improve absorption
- DIM should be taken consistently for at least 2-3 months, as hormonal changes take time
- Side effects are generally mild but may include digestive upset, headaches, or darker urine
- Those on hormone-sensitive medications, pregnant women, or individuals with hormone-dependent conditions should consult with a healthcare provider before starting DIM supplementation, as it may interact with their condition or treatment It is essential to note that while DIM may help with estrogen clearance, its effectiveness can vary depending on individual factors, and more research is needed to fully understand its potential benefits and limitations, as highlighted in a study published in 2023 2. Additionally, other studies have explored the relationship between omega-3 and omega-6 fatty acids and endometriosis, but these findings are not directly related to the mechanism of DIM in estrogen clearance 3, 4. A review of dietary supplements for the treatment of endometriosis published in 2022 also discussed the potential benefits of various supplements, including vitamin D, zinc, and omega 3, but did not specifically focus on DIM 5. Overall, the most recent and highest-quality study on the topic, published in 2024, provides the strongest evidence for the mechanism of DIM in estrogen clearance 1.