From the Guidelines
A mildly decreased INR level implies a higher risk of thromboembolism in patients with mechanical heart valves.
Implications of a Mildly Decreased INR
- The risk of thromboembolism increases when the INR falls below the therapeutic range, which can lead to serious complications such as stroke or valve thrombosis 1.
- For patients with mechanical aortic valve replacements, an INR target of 2.5 (range, 2.0–3.0) provides a reasonable balance between the risks of thromboembolism and bleeding 1.
- In patients with mechanical mitral valve replacements, anticoagulation with warfarin is recommended with an INR target of 3.0 (range, 2.5–3.5) to minimize the risk of thromboembolism 1.
- The incidence of thromboembolism is higher in patients with mechanical prostheses in the mitral compared with the aortic position, and the rate of thromboembolism is lower in patients with a higher INR goal 1.
Management of a Mildly Decreased INR
- If the INR is mildly decreased, the patient's warfarin dose may need to be adjusted to achieve the target INR range 1.
- In patients at higher risk of thromboembolism, bridging anticoagulation with either intravenous UFH or subcutaneous LMWH may be recommended during the time interval when the INR is subtherapeutic preoperatively 1.
- Excessive anticoagulation (INR ≥5) greatly increases the risk of hemorrhage, while a rapid decrease in the INR that leads to INR falling below the therapeutic level increases the risk of thromboembolism 1. Some key points to consider when managing a mildly decreased INR include:
- The patient's individual risk factors for thromboembolism and bleeding
- The type and position of the mechanical heart valve
- The patient's compliance with warfarin therapy and INR monitoring
- The need for bridging anticoagulation during periods of subtherapeutic INR.
From the Research
Implication of a Mildly Decreased INR Level
- A mildly decreased INR level may not necessarily lead to an increased risk of thromboembolic events, as suggested by a study that found a target INR range of 2.0-2.5 to be acceptable for preventing thromboembolic events in patients with mechanical mitral valve replacement 2.
- However, a lower INR range may be associated with a higher rate of thromboembolism, as found in a systematic review and meta-analysis of randomized controlled trials in atrial fibrillation patients 3.
- On the other hand, a lower INR range may also be associated with a lower rate of major bleeding, as found in the same systematic review and meta-analysis 3.
- The relationship between INR levels and bleeding risk is complex, and factors such as age, renal failure, and alcohol use may also play a role in determining the risk of bleeding 4.
- In patients with a mildly decreased INR level, the risk of bleeding may be lower, but the risk of thromboembolic events may be higher, as suggested by a study that found a negative correlation between the log mean INR and all thromboembolic events 2.
Management of Mildly Decreased INR Levels
- The management of mildly decreased INR levels depends on various factors, including the patient's underlying condition, the presence of bleeding or thromboembolic events, and the patient's overall health status.
- In asymptomatic patients with an INR of ≤ 3.3, maintaining the same warfarin dose may be a reasonable approach, as suggested by a study that found no significant difference in outcomes between patients who maintained their warfarin dose and those who reduced their dose 5.
- However, in patients with a higher INR or an increased risk of hemorrhage, reducing the warfarin dose may be necessary to minimize the risk of bleeding 5.
- The decision to reduce the warfarin dose should be made on a case-by-case basis, taking into account the patient's individual risk factors and health status.