What is the dosage of intramuscular (IM) sumatriptan (Imigrain, Imitrex)?

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Last updated: March 29, 2025View editorial policy

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From the Guidelines

The recommended dosage of intramuscular (IM) sumatriptan is 6 mg, which can be repeated in one hour, with a maximal dosage of 12 mg per 24 hours. This dosage is based on the evidence from the American Family Physician journal, which provides a comprehensive overview of migraine management, including the use of triptans such as sumatriptan 1. The study highlights the importance of selecting the appropriate dosage and route of administration for each patient, taking into account the severity of their migraines and any potential contraindications. Some key points to consider when prescribing IM sumatriptan include:

  • The medication should be used for patients with moderate to severe migraines or mild to moderate migraines that are unresponsive to analgesics or NSAIDs
  • Contraindications to its use include ischemic vascular conditions, vasospastic coronary disease, uncontrolled hypertension, or other significant cardiovascular disease
  • The subcutaneous form of sumatriptan reaches peak blood concentrations faster than any other migraine-specific medications, with a peak concentration achieved in approximately 15 minutes
  • The efficacy of sumatriptan has been shown to be effective in 70 to 82 percent of patients, with some patients experiencing recurrence headaches that can be relieved with a second dose of the medication 1.

From the Research

Dosage of Intramuscular (IM) Sumatriptan

There are no research papers to assist in answering this question, as the provided studies do not mention the dosage of intramuscular (IM) sumatriptan. The studies focus on the comparison of antibiotics such as cefepime, piperacillin-tazobactam, and meropenem in various clinical settings, including the treatment of infections and febrile neutropenia 2, 3, 4, 5, 6.

  • Key points:
    • The studies do not provide information on sumatriptan dosage
    • The studies focus on antibiotic comparisons, not sumatriptan
    • No relevant data is available to answer the question about IM sumatriptan dosage

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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