Amoxicillin Dose Calculation for 8.28 kg Infant with Mild to Moderate Respiratory Infection
For an infant weighing 8.28 kg with a mild to moderate respiratory infection, administer amoxicillin 186 mg every 12 hours (total daily dose: 372 mg/day). 1
Dose Calculation
- Standard dosing for mild to moderate respiratory infections is 45 mg/kg/day divided into 2 doses (every 12 hours) 1, 2
- For this 8.28 kg infant: 45 mg/kg/day × 8.28 kg = 372 mg/day total
- Divided every 12 hours: 186 mg per dose, twice daily 1
Alternative Dosing Schedule
- If dosing every 8 hours is preferred: 40 mg/kg/day ÷ 3 doses = approximately 110 mg every 8 hours 3, 4
- Both schedules (every 12 hours and every 8 hours) are equally effective for lower respiratory tract infections 5
When to Use Higher Dosing
Consider 90 mg/kg/day (745 mg/day total, or 372 mg every 12 hours) if: 1, 2
- Severe infection is present
- High pneumococcal resistance in your area
- Recent antibiotic use within 4-6 weeks 3
- No clinical improvement after 48-72 hours 1
Practical Administration
- Use oral suspension for this age group 2
- Common concentration is 125 mg/5 mL or 250 mg/5 mL 4
- For 186 mg dose using 125 mg/5 mL suspension: administer 7.4 mL per dose
- Can be given with or without food, though food may improve tolerability 2
- Shake suspension well before each use 4
Treatment Duration
- Continue treatment for 7-10 days for respiratory infections 1
- Must continue for minimum 48-72 hours beyond symptom resolution 4