Humira Room Temperature Storage Duration
Humira (adalimumab) can be stored at room temperature up to 77°F (25°C) for a maximum of 14 days, after which it must be discarded if not used. 1
Primary Storage Requirements
- Refrigeration is the preferred storage method at 36°F to 46°F (2°C to 8°C), which maintains optimal stability until the manufacturer's expiration date 1
- The medication must be stored in its original carton to protect it from light exposure, regardless of storage temperature 1
- Humira should never be frozen; if frozen (even if subsequently thawed), the medication must be discarded as the biological structure is destroyed 1
Room Temperature Storage Guidelines
- When refrigeration is unavailable (such as during travel), Humira may be stored at room temperature up to 77°F (25°C) for up to 14 days 1
- Document the date when first removing Humira from the refrigerator in the spaces provided on the carton and dose tray to track the 14-day window 1
- After 14 days at room temperature, the medication must be thrown away even if unused 1
- The medication cannot be returned to refrigeration to "reset" this 14-day clock 1
Critical Temperature Limits
- Extreme temperatures (below 36°F/2°C or above 77°F/25°C) can rapidly degrade adalimumab and render it ineffective 2
- Direct sunlight exposure is prohibited and will compromise the medication 1
- Temperature excursions outside the recommended range accelerate degradation and potentially reduce therapeutic effectiveness 2
Visual Inspection Requirements
Before each use, inspect the liquid for cloudiness, discoloration, flakes, or particles 1
- If any of these visual changes are present, do not use the medication and contact the healthcare provider or pharmacist 1
- The presence of 1-2 small bubbles in the viewing window is normal and acceptable 1
Supporting Evidence for Biologic Stability
The 14-day room temperature allowance is based on extensive stability testing conducted by pharmaceutical manufacturers, who expose biologics to various temperature conditions to establish safe storage parameters 2. More concentrated biologic medications like Humira generally maintain potency better than diluted preparations when exposed to temperature variations 2. However, this does not extend the 14-day maximum, which represents the manufacturer's validated safety threshold 1.