From the Research
Metoprolol and Cabbage Consumption
- There is no direct evidence in the provided studies regarding the safety of restarting metoprolol after consuming cabbage.
- The studies primarily focus on the pharmacodynamic and pharmacokinetic properties of metoprolol, its therapeutic efficacy, and withdrawal phenomena 1, 2, 3, 4.
- One study discusses the treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy, but does not mention cabbage consumption 5.
- None of the studies investigate the interaction between metoprolol and cabbage or provide guidance on restarting metoprolol after consuming cabbage.
Withdrawal Phenomena and Metoprolol
- Studies have shown that abrupt withdrawal of metoprolol can lead to rebound increases in cardiac sensitivity to isoprenaline and resting heart rate 2, 4.
- Gradual withdrawal of metoprolol on a prolonged small dose can prevent or minimize these withdrawal phenomena 2, 4.
- However, these findings do not directly relate to the safety of restarting metoprolol after consuming cabbage.
Pharmacological Properties of Metoprolol
- Metoprolol is a beta1-selective adrenoceptor blocking drug with a longer duration of effect than expected from its half-life 1, 3.
- It is suitable for twice daily administration and has some pharmacodynamic and pharmacokinetic differences from other beta-adrenoceptor blocking drugs 1, 3.
- These properties do not provide information on the safety of restarting metoprolol after consuming cabbage.