Methylphenidate Oral Solution Available Doses
Methylphenidate hydrochloride oral solution is available in two concentrations: 5 mg per 5 mL and 10 mg per 5 mL, both supplied in 500 mL bottles as a colorless, grape-flavored liquid. 1
Formulation Details
- 5 mg/5 mL concentration: Each mL contains 1 mg of methylphenidate hydrochloride 1
- 10 mg/5 mL concentration: Each mL contains 2 mg of methylphenidate hydrochloride 1
- Both formulations are colorless, grape-flavored liquids 1
- Supplied in 500 mL bottles 1
Dosing Considerations with Oral Solution
For pediatric patients 6 years and older, the recommended starting dosage is 5 mg orally twice daily before breakfast and lunch (preferably 30 to 45 minutes before meals), with gradual increases of 5-10 mg weekly up to a maximum of 60 mg daily. 1
For adults, administer in divided doses 2 or 3 times daily, preferably 30 to 45 minutes before meals, with a maximum recommended daily dose of 60 mg and an average dosage of 20-30 mg daily. 1
Important Administration Notes
- The oral solution should be administered 30 to 45 minutes before meals 1
- For adults unable to sleep if medication is taken late in the day, administer the last dose before 6 p.m. 1
- Peak plasma concentration occurs within 1-2 hours after oral administration 1
- Food increases methylphenidate mean Cmax and AUC by approximately 13% and 25%, respectively, and delays Tmax by approximately 1 hour 1