What is the best treatment approach for a Steatocystoma multiplex flare-up?

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Last updated: November 10, 2025View editorial policy

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Treatment of Steatocystoma Multiplex Flare-Up

For acute inflammatory flare-ups of steatocystoma multiplex, the primary treatment is incision and drainage with extraction of the cyst wall using a modified surgical technique, which provides excellent cosmetic results and prevents recurrence.

Immediate Management of Inflamed Cysts

Surgical Intervention - First-Line Treatment

  • The modified surgical technique is the treatment of choice for inflamed steatocystoma multiplex lesions 1, 2
  • Puncture inflamed cysts under local anesthesia using a sharp-tipped cautery point or radiofrequency instrument 3, 1
  • Evacuate cyst contents by gentle squeezing with fine forceps 1
  • Extract the entire cyst wall through the small opening using forceps to prevent recurrence 3, 1
  • This approach is well-tolerated, time-efficient, and produces excellent cosmetic outcomes with minimal scarring 3, 1

Advantages of This Technique

  • Minimal blood loss compared to traditional excision 3
  • Practically no post-inflammatory hyperpigmentation or hypopigmentation 3
  • No recurrences observed in follow-up periods extending beyond 14 months 3, 1
  • Can treat multiple lesions (>50 cysts) in a single session 1

Management of Severely Inflamed Cases

When Multiple Cysts Are Actively Inflamed

  • Surgical incision, drainage, and electrocautery have proven beneficial for persistently infected, painful lesions 2
  • Prioritize treating the most symptomatic and inflamed cysts first 2
  • Stage procedures if the number of inflamed cysts is overwhelming, addressing the most problematic lesions initially 2

What NOT to Do

Avoid Isotretinoin During Flare-Ups

  • Do not initiate or continue isotretinoin therapy during an active flare-up 4
  • Isotretinoin can paradoxically cause rapid enlargement of pre-existing cysts and formation of new cysts in steatocystoma multiplex 4
  • If a patient is already on isotretinoin when flare occurs, discontinue the medication 4
  • While isotretinoin may improve inflamed cysts initially, it can subsequently exacerbate the condition after 8 weeks of therapy 4

Avoid Incomplete Procedures

  • Simple aspiration without cyst wall removal leads to recurrence 3
  • Traditional wide surgical excision is unnecessarily aggressive and produces inferior cosmetic results 1
  • Cryosurgery alone is inadequate for treating inflamed lesions 3

Post-Procedure Management

  • Monitor treated sites for signs of infection or recurrence 3, 1
  • Follow-up at regular intervals to assess for new cyst formation 3, 1
  • Counsel patients that this is an office-based procedure with minimal downtime 3

Special Considerations

  • The procedure can be performed under local anesthesia in an outpatient setting 3, 1
  • No special equipment beyond basic surgical instruments and cautery/radiofrequency device is required 3, 1
  • Complications during or after the procedure are rare when proper technique is employed 3, 1

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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