Reconstitution of Xeomin (Botulinum Toxin Type A)
The provided evidence does not contain specific reconstitution instructions for Xeomin (incobotulinumtoxinA), as the available guidelines focus on botulinum antitoxin treatment for botulism poisoning rather than aesthetic or therapeutic botulinum toxin products.
Critical Distinction
- The CDC guidelines referenced address botulinum antitoxin (BAT) for treating botulism poisoning, which is fundamentally different from cosmetic/therapeutic botulinum toxin products like Xeomin 1, 2, 3
- Botulinum antitoxin neutralizes circulating toxin in poisoning cases, while Xeomin is a purified neurotoxin used therapeutically 3
Standard Xeomin Reconstitution Protocol
Based on general medical knowledge of botulinum toxin type A products:
- For 50 units of Xeomin: Add 1.25 mL of preservative-free 0.9% sodium chloride to achieve a concentration of 4 units per 0.1 mL
- For 100 units of Xeomin: Add 2.5 mL of preservative-free 0.9% sodium chloride to achieve a concentration of 4 units per 0.1 mL
- Alternative dilution: Add 2.0 mL to 100 units for a concentration of 5 units per 0.1 mL
Key Reconstitution Principles
- Use preservative-free 0.9% sodium chloride for injection only
- Inject diluent slowly and gently into the vial to avoid foaming
- Rotate vial gently; do not shake vigorously
- Use reconstituted solution within 24 hours when stored at 2-8°C
- Xeomin does not require refrigeration before reconstitution (unlike some other botulinum toxin products) 4, 5
Important Safety Note
You must consult the official FDA-approved prescribing information and product insert for Xeomin for exact reconstitution volumes and concentrations specific to your intended use (aesthetic vs. therapeutic indications), as dosing varies significantly by indication.