Which patients would benefit from the use of Diindolylmethane (DIM)?

From the Research

Patients with triple-negative breast cancer (TNBC) may benefit from the use of DIM, as it has been shown to induce metabolic crisis and enhance the efficacy of certain anticancer agents, such as Centchroman, in this type of cancer. According to a recent study published in 2022 1, DIM promotes metabolic dysregulation in TNBC cells, which can lead to the inhibition of tumor growth.

The recommended dosage of DIM supplements is typically in the range of 100-300mg daily, taken with food to enhance absorption. For hormone balance, patients often take DIM continuously for 3-6 months before reassessing symptoms. DIM works by promoting healthy estrogen metabolism, specifically by increasing the conversion of estrogen to its beneficial 2-hydroxy metabolites rather than the potentially harmful 16-hydroxy metabolites, as shown in a study published in 2017 2.

Some key points to consider when using DIM supplements include:

• DIM may also benefit patients with acne related to hormonal imbalances and those experiencing symptoms of perimenopause.
• Patients should be aware that mild side effects may include digestive upset, darker urine, and headaches when starting supplementation.
• Those taking medications metabolized by cytochrome P450 enzymes should consult healthcare providers before using DIM due to potential interactions, as highlighted in a study published in 2021 3.
• The use of DIM in patients with polycystic ovary syndrome (PCOS) may also be beneficial, as PCOS is associated with an increased risk of endometrial cancer, and DIM has been shown to have anticancer properties, as discussed in a review published in 2016 4.

Overall, the use of DIM supplements may be beneficial for patients with certain types of hormone-sensitive cancers, such as TNBC, and those with estrogen-dominant conditions, such as endometriosis and uterine fibroids. However, it is essential to consult with a healthcare provider before starting DIM supplementation, especially for patients with underlying medical conditions or those taking certain medications.