What is the choroid plexus in the brain?

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Last updated: February 12, 2025View editorial policy

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From the Guidelines

The choroid plexus is a small, fluid-filled structure within the choroid of the lateral ventricles of the brain.

Key Characteristics

  • Located in the lateral ventricles of the brain
  • Appears as echolucent cysts within the echogenic choroid on ultrasound
  • May be single or multiple, unilateral or bilateral, and most often are <1 cm in diameter
  • Identified in approximately 1% to 2% of fetuses in the second trimester of pregnancy

Clinical Significance

  • Associated with trisomy 18, but also commonly found in fetuses with euploidy
  • Presence of a choroid plexus cyst does not alter the risk of trisomy 21 1
  • Neurodevelopmental outcomes in children with euploidy born after a prenatal diagnosis of choroid plexus cysts have not shown differences in neurocognitive ability, motor function, or behavior 1

Diagnostic Considerations

  • Ultrasound characteristics of choroid plexus cysts (size, complexity, laterality, and persistence) should not be used to modify risk further 1
  • Choroid plexus tumors can arise in association with the ventricular system (intraventricular/paraventricular) 1

From the Research

Definition and Structure of the Choroid Plexus

  • The choroid plexus is an epithelial-endothelial vascular convolute within the ventricular system of the vertebrate brain 2.
  • It consists of epithelial cells, fenestrated blood vessels, and the stroma, which may contain various cell types and a rich extracellular matrix 2.
  • The choroid plexus is mainly involved in the production of cerebrospinal fluid (CSF) by using the free access to the blood compartment of the leaky vessels 2.

Functions of the Choroid Plexus

  • The choroid plexus is responsible for producing most of the CSF that fills the brain ventricles and the subarachnoid space, which is renewed approximately 2-3 times daily 3.
  • It contains an impressive number of receptors and transporters, both in the apical and basolateral sides of the epithelial cells, and is a key structure for the communication between the brain and the periphery 3.
  • The choroid plexus plays a role in regulating brain metabolism and function, and its activity influences brain development and function 4, 5.

Role in Brain Development and Disease

  • The choroid plexus is involved in the regulation of neural stem cell behavior and neurogenesis during brain development 6.
  • It is a site of origin of extrinsic regulation of neural stem cells, and regulated secretion of signaling molecules from the choroid plexus into CSF can regulate neural stem cell behavior 6.
  • The choroid plexus is involved in various neurological disorders, including neurodegenerative, inflammatory, infectious, traumatic, neoplastic, and systemic diseases 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Choroid plexus: biology and pathology.

Acta neuropathologica, 2010

Research

Regulation of choroid plexus development and its functions.

Cellular and molecular life sciences : CMLS, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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