What is the treatment for Candida (fungal infection) overgrowth in the stool?

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Last updated: March 29, 2025View editorial policy

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From the FDA Drug Label

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From the Research

To treat stool candida, the most effective approach is to combine oral antifungal medications, such as nystatin, with dietary modifications, as evidenced by a study published in 2018 1. This approach has been shown to have better outcomes in treating intestinal Candida overgrowth compared to using antifungals alone. The study found that patients who adhered to diet modification during and after treatment with nystatin had significantly higher cure rates after three months compared to those who only received nystatin.

Key components of the treatment plan include:

  • Oral antifungal medications like nystatin (500,000-1,000 units three times daily for 7-14 days) or fluconazole (150-200 mg daily for 7-14 days) 2, 3
  • Dietary changes to reduce sugar and refined carbohydrates while increasing probiotic-rich foods like yogurt with live cultures
  • Probiotics containing Lactobacillus and Bifidobacterium species (at least 10 billion CFU daily) to help restore gut flora balance
  • Ensuring adequate hydration and considering supplements like caprylic acid (1,000-2,000 mg daily with meals) or garlic extract

It's essential to note that the treatment of stool candida should prioritize reducing morbidity, mortality, and improving quality of life. Therefore, the treatment plan should be tailored to the individual patient's needs, and the healthcare provider should be consulted if symptoms persist despite treatment, as persistent candidiasis may indicate an underlying condition requiring additional evaluation and management 4, 5.

In terms of specific treatment protocols, a study published in 2016 found that nystatin pastille was significantly superior to placebo in treating denture stomatitis, while nystatin suspension was not superior to fluconazole in treating oral candidiasis in infants, children, or HIV/AIDS patients 5. However, the most recent and highest-quality study, published in 2022, found that fluconazole therapy resulted in significant improvements in clinical, histologic, and calprotectin levels in patients with active ulcerative colitis who had detectable Candida in the stool 3.

Overall, the treatment of stool candida requires a comprehensive approach that combines oral antifungal medications, dietary modifications, and probiotics to restore gut flora balance and improve patient outcomes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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