Does orgasm affect the efficacy of Vyvanse (lisdexamfetamine)?

From the Guidelines

No, orgasm does not kill or diminish the effects of Vyvanse (lisdexamfetamine). Vyvanse is a long-acting stimulant medication used to treat ADHD and binge eating disorder that works by being metabolized in the body to produce dextroamphetamine, which increases levels of neurotransmitters like dopamine and norepinephrine in the brain. The medication's effectiveness is based on its blood concentration levels and metabolism rate, which are not significantly altered by sexual activity or orgasm. While orgasm does temporarily release dopamine and other neurotransmitters, this brief neurochemical surge doesn't interfere with how Vyvanse is processed by your body or its ongoing therapeutic effects. The medication will continue working for its expected duration (typically 10-14 hours) regardless of sexual activity. If you feel the medication is becoming less effective, this is more likely due to factors like tolerance, timing of doses, food interactions, or sleep quality rather than sexual activity.

Key points to consider:

• The effectiveness of Vyvanse is determined by its blood concentration levels and metabolism rate, not by sexual activity or orgasm 1.
• Orgasm temporarily releases dopamine and other neurotransmitters, but this does not significantly impact the therapeutic effects of Vyvanse 1.
• Factors that may affect the efficacy of Vyvanse include tolerance, timing of doses, food interactions, and sleep quality, rather than sexual activity.
• Vyvanse is a long-acting medication with a duration of action of 10-14 hours, and its effects are not diminished by orgasm or sexual activity.

It's essential to note that the provided evidence does not directly address the relationship between orgasm and Vyvanse effects. However, based on the understanding of how Vyvanse works and the general principles of pharmacology, it can be concluded that orgasm does not significantly impact the medication's effectiveness. If concerns about the efficacy of Vyvanse arise, it is crucial to consult a healthcare professional to assess and address potential issues related to the medication regimen or underlying health conditions.

From the Research

Effects of Orgasm on Vyvanse

• There are no direct studies on the effects of orgasm on Vyvanse (2, 3, 4, 5, 6).
• The provided studies discuss the efficacy, safety, and pharmacokinetics of lisdexamfetamine dimesylate (Vyvanse) in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adults (2, 3, 4, 5, 6).
• No research papers were found to assist in answering the question of whether orgasm kills the effects of Vyvanse.

Pharmacokinetics and Efficacy of Vyvanse

• Lisdexamfetamine dimesylate is a prodrug that is therapeutically inactive until metabolized in the body to dextroamphetamine (2, 3, 4).
• The efficacy of Vyvanse in the treatment of ADHD has been established in several studies, with significant improvements in ADHD symptoms and overall quality of life (3, 4, 5, 6).
• Vyvanse has a long-acting properties, with efficacy lasting up to 14 hours post-dose in adults (3).

Safety and Tolerability of Vyvanse

• The most common adverse events reported with Vyvanse include decreased appetite, insomnia, upper abdominal pain, headache, irritability, weight loss, and nausea (4, 5, 6).
• Vyvanse has a safety profile consistent with long-acting stimulants use (3, 4, 5, 6).