What are the brand names of thiazide diuretics?

Thiazide Diuretic Brand Names

The most commonly used thiazide and thiazide-like diuretics are available under multiple brand names, with hydrochlorothiazide, chlorthalidone, and indapamide being the primary agents in this class.

Single-Agent Thiazide Diuretics

Hydrochlorothiazide

• Hydrochlorothiazide is available as a generic medication and is the most widely prescribed thiazide diuretic in the United States 1, 2
• The drug is supplied in various strengths including 12.5 mg capsules for oral use 3

Chlorthalidone

• Chlorthalidone is available primarily as a generic medication 4
• This agent has been used extensively in major cardiovascular outcome trials and is increasingly recognized as a preferred thiazide-like diuretic 5, 2

Indapamide

• Indapamide is another thiazide-like diuretic available for hypertension management 6
• This agent is recommended alongside chlorthalidone as a preferred diuretic due to its longer duration of action 5

Combination Products with Thiazide Diuretics

ACE Inhibitor + Hydrochlorothiazide Combinations

• Lotensin HCT: Benazepril-hydrochlorothiazide (5/6.25,10/12.5,20/12.5,20/25 mg) 7
• Capozide: Captopril-hydrochlorothiazide (25/15,25/25,50/15,50/25 mg) 7
• Vaseretic: Enalapril-hydrochlorothiazide (5/12.5,10/25 mg) 7
• Monopril/HCT: Fosinopril-hydrochlorothiazide (10/12.5,20/12.5 mg) 7
• Prinzide, Zestoretic: Lisinopril-hydrochlorothiazide (10/12.5,20/12.5,20/25 mg) 7
• Uniretic: Moexipril-hydrochlorothiazide (7.5/12.5,15/25 mg) 7
• Accuretic: Quinapril-hydrochlorothiazide (10/12.5,20/12.5,20/25 mg) 7

ARB + Hydrochlorothiazide Combinations

• Atacand HCT: Candesartan-hydrochlorothiazide (16/12.5,32/12.5 mg) 7
• Teveten-HCT: Eprosartan-hydrochlorothiazide (600/12.5,600/25 mg) 7
• Avalide: Irbesartan-hydrochlorothiazide (150/12.5,300/12.5 mg) 7
• Hyzaar: Losartan-hydrochlorothiazide (50/12.5,100/25 mg) 7
• Benicar HCT: Olmesartan medoxomil-hydrochlorothiazide (20/12.5,40/12.5,40/25 mg) 7
• Micardis-HCT: Telmisartan-hydrochlorothiazide (40/12.5,80/12.5 mg) 7
• Diovan-HCT: Valsartan-hydrochlorothiazide (80/12.5,160/12.5,160/25 mg) 7

Beta-Blocker + Thiazide Combinations

• Tenoretic: Atenolol-chlorthalidone (50/25,100/25 mg) 7
• Ziac: Bisoprolol-hydrochlorothiazide (2.5/6.25,5/6.25,10/6.25 mg) 7
• Lopressor HCT: Metoprolol-hydrochlorothiazide (50/25,100/25 mg) 7
• Corzide: Nadolol-bendroflumethiazide (40/5,80/5 mg) 7
• Inderide LA: Propranolol LA-hydrochlorothiazide (40/25,80/25 mg) 7
• Timolide: Timolol-hydrochlorothiazide (10/25 mg) 7

Potassium-Sparing Diuretic + Thiazide Combinations

• Moduretic: Amiloride-hydrochlorothiazide (5/50 mg) 7
• Aldactazide: Spironolactone-hydrochlorothiazide (25/25,50/50 mg) 7
• Dyazide, Maxzide: Triamterene-hydrochlorothiazide (37.5/25,75/50 mg) 7

Other Combinations with Thiazides

• Aldoril: Methyldopa-hydrochlorothiazide (250/15,250/25,500/30,500/50 mg) 7
• Demi-Regroton, Regroton: Reserpine-chlorthalidone (0.125/25,0.25/50 mg) 7
• Hydropres: Reserpine-hydrochlorothiazide (0.125/25,0.125/50 mg) 7

Important Clinical Considerations

Dosing Equivalence

• The equivalent dose of hydrochlorothiazide for 25 mg chlorthalidone is 50 mg, as chlorthalidone is approximately twice as potent 5
• Successful morbidity trials used doses equivalent to 25-50 mg of hydrochlorothiazide or 12.5-25 mg of chlorthalidone 7

Generic Availability

• Most thiazide diuretics, including hydrochlorothiazide and chlorthalidone, are now available in generic formulations, which has significantly reduced prescription costs 7
• The use of generic drugs should be considered to reduce prescription costs, and separate generic prescriptions may cost less than non-generic fixed-dose combinations 7