From the Research
Journavx (bempedoic acid) can be used with simvastatin, but caution is advised due to potential drug interactions. When used together, the recommended maximum dose of simvastatin should be limited to 20 mg daily to reduce the risk of side effects. This combination may be prescribed for patients who need additional LDL cholesterol lowering beyond what simvastatin alone can provide. The interaction occurs because bempedoic acid can increase blood levels of simvastatin by affecting how it's metabolized in the liver, potentially increasing the risk of muscle-related side effects (myopathy or rhabdomyolysis) 1. Patients taking this combination should report any unexplained muscle pain, tenderness, or weakness to their healthcare provider immediately. Regular monitoring of liver function and muscle enzymes (CK levels) is typically recommended when using these medications together 2. This combination therapy should only be used under close medical supervision with appropriate dose adjustments. Some key points to consider when prescribing this combination include:
- The potential for increased risk of myopathy or rhabdomyolysis due to the interaction between bempedoic acid and simvastatin 3
- The importance of monitoring liver function and muscle enzymes (CK levels) regularly 4
- The need for close medical supervision and appropriate dose adjustments when using this combination therapy 5