What is the proper way to take Erleada (apalutamide)?

How to Take Erleada (Apalutamide)

Standard Administration

Take Erleada 240 mg orally once daily, either as one 240 mg tablet or four 60 mg tablets, swallowed whole with or without food. 1

• Do not crush or split the tablets 1
• Timing flexibility: Erleada can be taken at any time of day, with or without meals 1
• Concurrent therapy required: Patients must also receive a GnRH analog concurrently or have had bilateral orchiectomy 1

Alternative Administration Methods

For Patients Who Cannot Swallow Tablets Whole

If you cannot swallow tablets whole, disperse the tablets in non-carbonated water and mix with orange juice, applesauce, or additional water: 1

For 240 mg tablet:

• Place the whole tablet in a cup (do not crush or split) 1
• Add 2 teaspoons (10 mL) of non-carbonated water to completely immerse the tablet 1
• Wait 2 minutes until the tablet breaks up and spreads out, then stir 1
• Add 2 tablespoons (30 mL) of orange juice, applesauce, or additional water and stir 1
• Swallow the mixture immediately 1
• Rinse the cup with water to ensure the full dose is taken and drink immediately 1

For 60 mg tablets (any prescribed dose):

• Place all prescribed tablets in a cup (do not crush or split) 1
• Add 4 teaspoons (20 mL) of non-carbonated water to completely immerse the tablets 1
• Follow the same steps as above for waiting, stirring, mixing, and rinsing 1

Critical warning: Do not store Erleada mixed with water, orange juice, or applesauce for later use 1

For Patients With Feeding Tubes

Erleada can be administered through feeding tubes 8 French or larger: 1

For 240 mg tablet:

• Use at least a 20 mL syringe 1
• Place the tablet in the syringe barrel and draw up 10 mL of non-carbonated water 1
• Wait 10 minutes, then shake vigorously to disperse completely 1
• Administer immediately through the feeding tube 1
• Refill with water and flush; repeat until no residue remains 1

For 60 mg tablets:

• Use at least a 50 mL syringe 1
• Place all prescribed tablets in the syringe barrel and draw up 20 mL of non-carbonated water 1
• Follow the same steps as above for waiting, shaking, administering, and flushing 1

Storage Requirements

• Store at room temperature between 68°F to 77°F (20°C to 25°C) 1
• Keep in the original child-resistant bottle to protect from light and moisture 1
• Do not discard the desiccant packet in the bottle 1

Common Pitfalls to Avoid

Never crush or split tablets under any circumstances, even when using alternative administration methods 1

Do not use carbonated water for dispersing tablets—only non-carbonated water is appropriate 1

Avoid storing prepared mixtures—all dispersed tablet preparations must be administered immediately 1