What is the correct dose for Journavx?

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Last updated: November 12, 2025View editorial policy

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Journavx (Suzetrigine) Dosing Information

I cannot provide specific dosing information for Journavx from the evidence provided, as none of the sources contain FDA-approved prescribing information or dosing guidelines for this medication. 1

What We Know About Journavx

  • Journavx (suzetrigine) is a newly FDA-approved medication (approved January 30,2025) for the treatment of moderate to severe acute pain in adults in the United States 1

  • It represents the first non-opioid analgesic approved in over two decades and is the first-in-class selective NaV1.8 sodium channel inhibitor 1, 2

  • The medication is administered orally and works by blocking NaV1.8 channels located along peripheral pain-sensing neurons 1

Critical Next Steps for Prescribing

To obtain the correct dosing information for Journavx, you must:

  • Consult the FDA-approved package insert/prescribing information that accompanies the medication, as this will contain the official dosing recommendations 3

  • Contact Vertex Pharmaceuticals Inc. (the manufacturer) or their medical information department for specific dosing guidance 1

  • Consult with a pharmacist who can access the most current prescribing information and provide specific dosing recommendations 3

Important Clinical Context

  • Current evidence shows Journavx has been studied primarily for short-duration treatment of acute pain perioperatively for minimally to moderately painful ambulatory procedures 2

  • Patient-specific factors that typically influence dosing include weight, age, and renal function, though the specific adjustments for Journavx are not detailed in the available evidence 3

  • Long-term efficacy and safety data are still limited, as all current studies focus on short treatment durations 2

References

Research

Beyond Opioids: A Review of Suzetrigine for Acute Pain Management.

International journal of molecular sciences, 2025

Guideline

Medication Dosing Considerations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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