From the Research
Management of Hydroxide Overdose
The management of hydroxide overdose, including sodium hydroxide and calcium hydroxide, is crucial to prevent further complications.
- In cases of sodium hydroxide ingestion, the corrosive effects can lead to severe tissue damage and necrosis, as seen in a case study where a man ingested sodium hydroxide solution, resulting in liquefaction and disappearance of esophagus, trachea, and lung tissue 1.
- For calcium hydroxide, its use in endodontic treatments has been well-documented, with studies showing its effectiveness in infection control and promoting periodontal healing 2, 3.
- However, long-term dressing with calcium hydroxide has been suggested to weaken the root and increase the susceptibility of teeth to fracture, although recent studies have shown that this may not be the case 4.
- In terms of inactivating prions, sodium hydroxide has been shown to lead to substantial but incomplete inactivation, while combining autoclaving with sodium hydroxide treatment is extremely effective 5.
Treatment Approaches
- The treatment of hydroxide overdose typically involves addressing the corrosive effects and managing the resulting tissue damage.
- In the case of sodium hydroxide ingestion, immediate medical attention is necessary to prevent further complications.
- For calcium hydroxide, its use in endodontic treatments should be carefully monitored to minimize the risk of tooth fracture and ensure effective infection control.
- Further research is needed to fully understand the effects of hydroxide overdose and to develop effective management strategies.