What is the cause of acute, non-painful, bilateral vision loss during hemodialysis (hemodialysis)?

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Last updated: March 30, 2025View editorial policy

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Differential Diagnosis for Acute Non-Painful Bilateral Vision Loss During Hemodialysis

  • Single Most Likely Diagnosis
    • Dialysis disequilibrium syndrome: This condition occurs due to the rapid removal of urea from the blood during hemodialysis, leading to cerebral edema. It can cause a range of symptoms including vision changes, making it a plausible cause for acute non-painful bilateral vision loss during hemodialysis.
  • Other Likely Diagnoses
    • Hypotension: A common complication during hemodialysis, hypotension can lead to decreased blood flow to the optic nerves and retina, resulting in vision loss.
    • Electrolyte imbalance: Hemodialysis can cause shifts in electrolyte levels, such as potassium, sodium, and calcium, which are crucial for nerve function. An imbalance can affect the optic nerves and lead to vision changes.
    • Uremic optic neuropathy: Although less common, uremic optic neuropathy can occur in patients with end-stage renal disease, especially during hemodialysis, causing vision loss.
  • Do Not Miss Diagnoses
    • Stroke or cerebral vasospasm: Although less likely, a stroke or cerebral vasospasm can occur during hemodialysis and cause sudden vision loss. Missing this diagnosis could be catastrophic.
    • Air embolism: An air embolism during hemodialysis can lead to cerebral embolism, causing sudden vision loss among other symptoms. Prompt recognition is crucial.
  • Rare Diagnoses
    • Cortical blindness due to posterior reversible encephalopathy syndrome (PRES): This is a rare condition that can occur due to severe hypertension or other factors during hemodialysis, leading to vision loss.
    • Thrombosis or embolism of the ophthalmic arteries: Although rare, these conditions can cause sudden vision loss and should be considered in the differential diagnosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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