How to Bathe with Chlorhexidine 2%
Daily bathing with 2% chlorhexidine gluconate solution is recommended for ICU patients over two months of age to reduce healthcare-associated infections, applied to the entire body surface while avoiding eyes, ears, and mucous membranes, allowing the solution to remain on the skin briefly before rinsing. 1
Patient Selection and Safety Considerations
Who should receive chlorhexidine bathing:
- ICU patients aged over two months 1
- Adult hematology-oncology patients may benefit 1
- Patients with central venous catheters at high risk for bloodstream infections 1
Critical contraindications and warnings:
- Do NOT use in infants under two months of age - life-threatening skin injuries have been reported, especially in infants with birth weight below 1,000 grams who are less than 7 days postnatal age 1
- Avoid contact with eyes - can cause conjunctivitis and severe corneal damage 1, 2
- Avoid contact with ears - ototoxicity precludes use in or near the middle/inner ear 1, 2
- Do not apply to brain tissue or meninges 1, 2
Step-by-Step Bathing Procedure
Preparation:
- Use 2% chlorhexidine gluconate solution (not the 4% concentration used for surgical hand scrubs) 1
- Chlorhexidine-impregnated washcloths are an effective alternative delivery method 1
- Perform hand hygiene before assisting with patient bathing 1
Application technique:
- Apply the 2% chlorhexidine solution to the entire body surface systematically 1
- Use gentle mechanical friction during application to enhance antimicrobial activity 1
- Avoid these areas: eyes, ears, mucous membranes, and open wounds 1, 2
- Allow the antiseptic solution to remain on the skin briefly for antimicrobial effect 1
- The solution can then be rinsed off with water 1
Frequency:
- Perform daily bathing for ICU patients 1
- Continue throughout the ICU stay or while central venous catheters are in place 1
Expected Outcomes and Effectiveness
Proven benefits:
- 23% reduction in multidrug-resistant organism acquisition (5.10 vs 6.60 cases per 1,000 patient-days) 1
- 28% reduction in hospital-acquired bloodstream infections (4.78 vs 6.60 cases per 1,000 patient-days) 1
- Significant reduction in central line-associated bloodstream infections in ICU patients 1
- Chlorhexidine has substantial residual antimicrobial activity that persists on the skin after application 1, 2
Uncertain effectiveness:
- The benefit in non-ICU patients remains uncertain, though one cluster-randomized study showed reduction in central line infections 1
- Pediatric hematology-oncology patients did not show the same benefit as adults 1
Common Pitfalls and How to Avoid Them
Skin reactions:
- Products containing 4% chlorhexidine (used for hand hygiene) are most likely to cause dermatitis with frequent use - ensure you are using the 2% concentration for bathing 1, 2
- Adverse effects occurred in 71% of patients using 4% whole-body washing versus 33% with placebo, but were reversible in most cases 3
- Monitor for skin irritation, which is concentration-dependent 1
Incomplete coverage:
- Groin-area colonization responds particularly well to chlorhexidine bathing 3
- Ensure systematic coverage of all body surfaces except contraindicated areas 1
- Whole-body washing alone may not eradicate colonization in the gastrointestinal tract or wounds 3
Timing considerations:
- For patients with ostomies or fistulae, temporally separate ostomy/fistula care from chlorhexidine bathing 1
- Avoid catheter care immediately after changing or emptying ostomy appliances 1
- Perform hand hygiene after ostomy care before proceeding with bathing 1
Drug interactions: