How do I bathe with chlorhexidine (CHG) 2 percent solution?

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How to Bathe with Chlorhexidine 2%

Daily bathing with 2% chlorhexidine gluconate solution is recommended for ICU patients over two months of age to reduce healthcare-associated infections, applied to the entire body surface while avoiding eyes, ears, and mucous membranes, allowing the solution to remain on the skin briefly before rinsing. 1

Patient Selection and Safety Considerations

Who should receive chlorhexidine bathing:

  • ICU patients aged over two months 1
  • Adult hematology-oncology patients may benefit 1
  • Patients with central venous catheters at high risk for bloodstream infections 1

Critical contraindications and warnings:

  • Do NOT use in infants under two months of age - life-threatening skin injuries have been reported, especially in infants with birth weight below 1,000 grams who are less than 7 days postnatal age 1
  • Avoid contact with eyes - can cause conjunctivitis and severe corneal damage 1, 2
  • Avoid contact with ears - ototoxicity precludes use in or near the middle/inner ear 1, 2
  • Do not apply to brain tissue or meninges 1, 2

Step-by-Step Bathing Procedure

Preparation:

  • Use 2% chlorhexidine gluconate solution (not the 4% concentration used for surgical hand scrubs) 1
  • Chlorhexidine-impregnated washcloths are an effective alternative delivery method 1
  • Perform hand hygiene before assisting with patient bathing 1

Application technique:

  • Apply the 2% chlorhexidine solution to the entire body surface systematically 1
  • Use gentle mechanical friction during application to enhance antimicrobial activity 1
  • Avoid these areas: eyes, ears, mucous membranes, and open wounds 1, 2
  • Allow the antiseptic solution to remain on the skin briefly for antimicrobial effect 1
  • The solution can then be rinsed off with water 1

Frequency:

  • Perform daily bathing for ICU patients 1
  • Continue throughout the ICU stay or while central venous catheters are in place 1

Expected Outcomes and Effectiveness

Proven benefits:

  • 23% reduction in multidrug-resistant organism acquisition (5.10 vs 6.60 cases per 1,000 patient-days) 1
  • 28% reduction in hospital-acquired bloodstream infections (4.78 vs 6.60 cases per 1,000 patient-days) 1
  • Significant reduction in central line-associated bloodstream infections in ICU patients 1
  • Chlorhexidine has substantial residual antimicrobial activity that persists on the skin after application 1, 2

Uncertain effectiveness:

  • The benefit in non-ICU patients remains uncertain, though one cluster-randomized study showed reduction in central line infections 1
  • Pediatric hematology-oncology patients did not show the same benefit as adults 1

Common Pitfalls and How to Avoid Them

Skin reactions:

  • Products containing 4% chlorhexidine (used for hand hygiene) are most likely to cause dermatitis with frequent use - ensure you are using the 2% concentration for bathing 1, 2
  • Adverse effects occurred in 71% of patients using 4% whole-body washing versus 33% with placebo, but were reversible in most cases 3
  • Monitor for skin irritation, which is concentration-dependent 1

Incomplete coverage:

  • Groin-area colonization responds particularly well to chlorhexidine bathing 3
  • Ensure systematic coverage of all body surfaces except contraindicated areas 1
  • Whole-body washing alone may not eradicate colonization in the gastrointestinal tract or wounds 3

Timing considerations:

  • For patients with ostomies or fistulae, temporally separate ostomy/fistula care from chlorhexidine bathing 1
  • Avoid catheter care immediately after changing or emptying ostomy appliances 1
  • Perform hand hygiene after ostomy care before proceeding with bathing 1

Drug interactions:

  • Chlorhexidine's antimicrobial activity can be reduced by natural soaps, inorganic anions, nonionic surfactants, and hand creams containing anionic emulsifying agents 1
  • Do not use regular soap immediately before or after chlorhexidine application 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Chlorhexidine 4% Solution Efficacy and Safety

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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