TGL Slim Injectable Active Ingredient
The active ingredient in TGL Slim injectable is phosphatidylcholine, a naturally occurring phospholipid that has been used for subcutaneous fat reduction through its solubilizing agent deoxycholate, which is the actual adipolytic component.
Primary Active Component
- Phosphatidylcholine is marketed as the main ingredient in injectable fat reduction products, typically formulated at concentrations of 50-250 mg/mL 1, 2, 3.
- The therapeutic effect is primarily mediated by deoxycholate, a detergent used to solubilize phosphatidylcholine, which has direct adipolytic (fat-destroying) properties rather than lipolytic effects 4.
Mechanism of Action
- Phosphatidylcholine is a lecithin-derived phospholipid that functions as a structural component of cell membranes 5.
- When injected subcutaneously, the deoxycholate component acts as a detergent that disrupts adipocyte cell membranes, leading to localized fat reduction 4.
- The compound was initially developed for treating atheroma plaques in cardiac diseases before being repurposed for cosmetic fat reduction 1.
Clinical Formulations
- Standard injectable formulations contain phosphatidylcholine at 50-250 mg/mL concentration 1, 3.
- The product is administered via subcutaneous injection into localized fat deposits 1, 2.
- Treatment intervals typically range from 1-2 weeks between applications, with 3-5 treatments commonly required 1, 3.
Important Clinical Considerations
- Localized adverse effects occur in most patients but are predominantly mild: swelling (most common), erythema, burning/stinging, pain, tenderness, and bruising 2.
- Systemic side effects occur in approximately 3% of patients, including diarrhea, nausea, dizziness, and intermenstrual bleeding, with most being very mild to mild in severity 2.
- Efficacy varies significantly: 70-80% of patients report improvement, but 20-30% may be non-responders 3.
- Duration of effect is variable: 50% maintain benefit long-term (average 9 months follow-up), while 30% show no response 3.