What should be included in a primary care preventive screening schedule?

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Last updated: November 13, 2025View editorial policy

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Primary Care Preventive Screening Schedule

A comprehensive primary care preventive screening schedule should include age- and sex-specific cancer screenings, cardiovascular risk assessment, metabolic screening, immunizations, and behavioral health assessments, with the specific tests and intervals determined by patient age, sex, and risk factors. 1

Cancer Screening

Breast Cancer

  • Women should begin annual mammography at age 40 according to the American Cancer Society 1
  • The USPSTF recommends biennial screening mammography for women aged 50 to 74 years, with individualized decision-making for women aged 40-49 years 2
  • Women aged 60-69 years derive the greatest mortality benefit from screening 2

Cervical Cancer

  • Begin Pap testing at age 21 or when sexually active 2
  • After three consecutive normal annual Pap tests, screen every 3 years 2
  • For women aged 30-65 years, Pap test with HPV DNA testing every 5 years is an acceptable alternative 2, 1
  • Discontinue regular testing after age 65 if prior results have been consistently normal 2

Colorectal Cancer

  • Begin screening at age 50 for average-risk adults 2, 1
  • Recommended options include: 2, 1
    • Annual high-sensitivity fecal occult blood test (FOBT) or fecal immunochemical test (FIT)
    • Colonoscopy every 10 years
    • Flexible sigmoidoscopy every 5 years
    • CT colonography every 5 years
  • Continue screening until at least age 75 for those with life expectancy >10 years 3

Prostate Cancer

  • For men aged 55-69 years, engage in shared decision-making regarding PSA testing 1
  • Begin discussions at age 50 for average-risk men with at least 10-year life expectancy 2
  • Begin at age 45 for high-risk men (African-American or family history) 2
  • The USPSTF and Canadian Task Force do not recommend routine screening for the general population 2

Lung Cancer

  • Screen adults aged 55-80 years with annual low-dose CT if they have ≥30 pack-year smoking history and currently smoke or quit within the past 15 years 2, 4
  • Screening requires access to high-volume, high-quality screening and treatment centers 2

Cardiovascular Risk Assessment

  • Measure blood pressure annually in all adults 1, 3
  • Screen adults aged 40-75 years for lipid panel (total cholesterol, HDL, LDL, triglycerides) 1
  • Use ACC/AHA risk calculator to guide statin therapy decisions 3

Metabolic Screening

Diabetes

  • Screen with fasting glucose or hemoglobin A1C in adults aged 40-75 years 1, 3
  • Screen more frequently in adults with BMI ≥30 kg/m² 1

Thyroid

  • Screen with TSH test, particularly in women 1

Comprehensive Metabolic Panel

  • Perform CMP to assess kidney function, liver function, and electrolyte balance 1

Additional Recommended Screenings

Hematologic

  • Complete Blood Count (CBC) to screen for anemia, infection, and blood disorders 1

Urinary

  • Urinalysis to screen for kidney disease and urinary tract infections 1

Behavioral Health

  • Screen for depression and anxiety using standardized screening tools 1, 3
  • Assess alcohol use 3

Sexually Transmitted Infections

  • Screen for syphilis, gonorrhea, and chlamydia when indicated by risk factors 1

Cognitive Function (Age ≥65)

  • Screen using validated tools such as the Montreal Cognitive Assessment (MoCA) 3

Immunizations

  • Annual influenza vaccination for all adults 3
  • Pneumococcal vaccination as appropriate for age 3
  • Tetanus-diphtheria booster every 10 years 5

Cancer-Related Checkup

  • Perform cancer-related checkup every 3 years for ages 20-39, annually for age 40 and older 2
  • Include health counseling on tobacco, sun exposure, diet, nutrition, and risk factors 2
  • Examine thyroid, oral cavity, skin, lymph nodes, ovaries (women), and testicles (men) 2

System Factors to Improve Screening Rates

Common pitfall: Relying solely on opportunistic screening during acute care visits results in poor preventive care delivery 2

To maximize screening effectiveness: 1

  • Implement reminder systems to alert patients when screenings are due
  • Reduce organizational barriers to completing screening
  • Promote continuity in patient information and management
  • Address access barriers including insurance coverage and geographic distance

Critical consideration: A recommendation from a healthcare professional is among the strongest predictors of screening utilization 2. Regular preventive health examinations provide the best opportunity for comprehensive screening 2.

References

Guideline

Recommended Screening Tests for Primary Care

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Preventive Care for a 66-Year-Old Male Patient

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Check-up examination: recommendations in adults.

Swiss medical weekly, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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