Treatment of Croup in Children
Administer oral dexamethasone 0.15-0.6 mg/kg (maximum 10-12 mg) as a single dose to ALL children with croup regardless of severity, and add nebulized epinephrine only for moderate to severe cases. 1
Initial Assessment and Severity Classification
When evaluating a child with croup, focus on these key clinical indicators to determine severity:
- Stridor at rest indicates moderate to severe disease requiring nebulized epinephrine 1, 2
- Respiratory distress (retractions, nasal flaring, increased work of breathing) 1
- Oxygen saturation <92% is a hospitalization criterion 1
- Agitation may indicate hypoxia requiring oxygen therapy 2
Avoid unnecessary radiographic studies unless concerned about alternative diagnoses like bacterial tracheitis or foreign body aspiration 1, 2
Treatment Algorithm by Severity
Mild Croup
- Give oral dexamethasone alone (0.15-0.6 mg/kg, maximum 10-12 mg) 1
- Observe for 2-3 hours to ensure symptom improvement 3
- No nebulized treatments needed 3
Moderate to Severe Croup (stridor at rest or respiratory distress)
- Give oral dexamethasone (0.15-0.6 mg/kg, maximum 10-12 mg) 1
- Add nebulized epinephrine (0.5 ml/kg of 1:1000 solution, maximum 5 ml) 1, 3
- Observe for at least 2 hours after the last epinephrine dose to monitor for rebound symptoms 3, 2
- Administer oxygen to maintain saturation ≥94% 1, 2
Alternative corticosteroid option: Nebulized budesonide 2 mg is equally effective when oral administration is not feasible 1
Hospitalization Criteria
Consider admission after 3 doses of nebulized epinephrine rather than the traditional 2 doses—this approach reduces hospitalization rates by 37% without increasing revisits 4, 1, 3
Additional admission criteria include:
- Oxygen saturation <92% 1
- Age <18 months 1
- Respiratory rate >70 breaths/min 1
- Persistent difficulty breathing 1
Critical Pitfalls to Avoid
- Never discharge patients within 2 hours of nebulized epinephrine due to risk of rebound symptoms 1, 3, 2
- Do not withhold corticosteroids in mild cases—they reduce hospital admissions and complications 1, 5
- Avoid using nebulized epinephrine in outpatient settings where immediate discharge is planned 1, 3, 2
- Do not use humidified or cold air therapy—evidence shows no benefit 2, 6
- Avoid routine antibiotics as croup is viral 1
Discharge Criteria
Children can be discharged when they meet ALL of the following:
- Resolution of stridor at rest 1
- Minimal or no respiratory distress 1
- Adequate oral intake 1
- Parents can recognize worsening symptoms and know when to return 1, 2
Instruct families to follow up with their general practitioner if symptoms worsen or fail to improve within 48 hours 2