Daflon 1000 Dosing for Hemorrhoids and Chronic Venous Insufficiency
For acute hemorrhoidal disease, take Daflon 500 mg as 2 tablets (1000 mg) three times daily for 4 days, followed by 2 tablets (1000 mg) twice daily for 9 days. 1
Dosing Regimens by Indication
Acute Hemorrhoidal Crisis
- Days 1-4: 1000 mg (2 tablets of 500 mg) three times daily (total 3000 mg/day) 1
- Days 5-13: 1000 mg (2 tablets of 500 mg) twice daily (total 2000 mg/day) 1
- This intensive regimen targets the acute inflammatory phase when symptoms are most severe 2
Maintenance for Recurrent Hemorrhoids
- After acute resolution: 600 mg daily (approximately 1 tablet of 500 mg plus partial tablet, or as directed) for ongoing hemorrhoidal discomfort or recurrent flares 1
- This lower maintenance dose prevents symptom recurrence, though 80% of patients experience symptom return within 3-6 months after complete cessation 3
Chronic Venous Insufficiency (CVI)
- Standard dosing: 1000 mg daily (2 tablets of 500 mg once daily) 1, 4
- Results typically appear after 4-8 weeks of continuous treatment 1
- For venous ulcers specifically, improvement may require several months 1
- Long-term safety has been demonstrated for up to 12 months of continuous administration 5
Clinical Evidence Supporting These Doses
The micronized purified flavonoid fraction (MPFF) in Daflon works through multiple mechanisms: increasing venous tone, improving lymphatic drainage, reducing capillary hyperpermeability, and blocking the inflammatory cascade triggered by venous hypertension 6, 7. In controlled trials, the 1000 mg daily dose (2 tablets of 500 mg) significantly reduced hemorrhoidal attack frequency from 70% to 40%, shortened attack duration from 4.6 to 2.6 days, and decreased symptom severity scores from 4.0 to 1.1 compared to placebo 8.
Integration with Comprehensive Hemorrhoid Management
Daflon should be combined with first-line conservative measures including increased dietary fiber and water intake to soften stool, avoidance of straining during defecation, and regular sitz baths 3, 2. For thrombosed external hemorrhoids, add topical 0.3% nifedipine with 1.5% lidocaine ointment every 12 hours, which achieves 92% resolution rates 3. Short-term topical corticosteroids (≤7 days only) may reduce perianal inflammation but must be limited to prevent mucosal thinning 3, 2.
Important Considerations
Reassessment is mandatory if symptoms fail to improve within 1-2 weeks, as hemorrhoidal bleeding should never be assumed without proper evaluation—colonoscopy is warranted if there is concern for inflammatory bowel disease or colorectal cancer based on patient history 3, 2. Anemia from hemorrhoids is rare (0.5 per 100,000 population), so fecal occult blood or significant anemia requires full colonic evaluation before attributing it to hemorrhoids 3.
The excellent tolerability profile of Daflon has been confirmed in toxicology studies showing no substance-related alterations in acute, subacute, or chronic toxicity testing, with side effects limited primarily to mild gastralgia in approximately 3% of patients 4, 5. The micronized formulation allows for reliable gastrointestinal absorption and consistent therapeutic effects 4.