What features of Quinine toxicity do not include hypotension, ventricular bradycardia, supraventricular arrhythmia, hypoglycemia, and prolonged QRS complex?

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From the Research

Features of Quinine Toxicity

The features of quinine toxicity that do not include hypotension, ventricular bradycardia, supraventricular arrhythmia, hypoglycemia, and prolonged QRS complex are:

  • Ventricular tachycardia 1
  • Status epilepticus 1
  • Hypothermia 1
  • Coma 1
  • Reactive mydriasis 1
  • Bilateral retinal edema 1
  • Transitory bilateral blindness 1
  • Nausea, vomiting, and diaphoresis 2
  • Atrioventricular dissociation with escape His bundle or fascicular rhythm 2
  • QT prolongation 3, 4
  • Torsades de pointes (TdP) 3, 4
  • Sinus bradycardia 2
  • Bundle-branch block 2, 5
  • Cardiac index and left ventricular ejection fraction abnormalities 5
  • Right ventricular effective refractory period increase 5

Cardiovascular Side-Effects

Quinine poisoning can cause various cardiovascular side-effects, including:

  • Hypotension 1, 2, 5, 4
  • Abnormal myocardial conduction 1
  • Ventricular arrhythmias 1, 2, 5
  • Supraventricular arrhythmias 2, 5
  • Prolonged QRS complex 1, 2, 5
  • QT interval prolongation 3, 4

Treatment and Management

Quinine toxicity can be managed with various treatments, including:

  • Diazepam 1
  • Lidocaine 1
  • Methylprednisolone 1
  • Glycerol 1
  • Furosemide 1
  • Adrenaline 1
  • Dobutamine 1
  • Albumin infusion 1
  • Plasma volume expander 1
  • Sodium thiopental 1
  • Saline solution infusion 5

References

1
Research

[Acute quinine poisoning treated with high dose of diazepam].

Archives francaises de pediatrie, 1993

5
Research

Safety and efficacy of intravenous quinidine.

The American journal of medicine, 1983

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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